Guillain-Barré Syndrome Flashcards Preview

Foundations II Exam 4 (Jess) > Guillain-Barré Syndrome > Flashcards

Flashcards in Guillain-Barré Syndrome Deck (18):
1

What is Guillain-Barré Syndrome?

idiopathic acute/subacute inflammatory demyelinating polyneuropathy

2

MC microorganism a/w Guillain-Barré Syndrome?

Campylobacter jejuni

others:
EBV, cytomegalovirus, HIV, Zika

3

Guillain-Barré Syndrome is the MC cause of ____ ?

acute atraumatic generalized paralysis in all age groups

4

Explain the pathophys of Guillain-Barré Syndrome

-antecedent infection invokes immune response

-antibody production

-antibodies attach to peripheral nerve cells (molecular mimicry)

-macrophages attack peripheral nerves

-acute polyneuropathy
(select antibodies attack axons/myelin)

5

What is the MC variant of GBS? what is it?

Acute inflammatory demyelinating polyneuropathy (AIDP)

-progressive symmetric weakness accompanied by absent or depressed DTRs

-Paresthesias in the hands and feet

6

Characteristics of Acute Motor Axonal Neuropathy

-Japan and China
-DTRs may be preserved
-no sensory involvement

7

Characteristics of Acute motor and sensory axonal neuropathy

-AMAN + sensory nerve involvement
-Higher severity than AMAN

8

Characteristics of Miller Fisher syndrome

-Ophthalmoplegia w/ ataxia and areflexia
-only 25% develop extremity weakness

9

What happens to the CSF in GBS?

-macrophages damage the peripheral nerve dural attachment
-breakdown of the peripheral nerve CSF
-allows passage of proteins into CSF

10

What are sx of GBS?

-Progressive SYMMETRIC ascending muscle weakness weakness and diminished DTRs
-Neuropathic pain
-Sensory presentation
-Gait disturbance- ataxic component out of proportion to the muscle weakness

-cranial nerve may be involved
-respiratory failure

11

What part of the body is initially affected in GBS?

Lower extremities
progressively involves the trunk
then upper extremities
-ultimately paralysis

12

What is needed for dx of GBS?

LP
-elevated protein w/ nl WBC (albuminocytologic dissociation)

13

When performing a LP for GBS, what do you need to consider?

-usually nl in 1st 2-3 days
-90% will be abnormal at 1 week
-peak is 3-6 weeks

14

What do you need to classify GBS?
You would defer this to electrophysiologist

Nerve conduction studies (NCS)
needle electromyography (EMG)

15

How do you treat GBS?

Supportive Care:
-Hospitalization
-DVT prophylaxis
-close monitoring of respiratory and cardiovascular fxn

Immunotherapy
Plasmapheresis (to remove antibodies)

16

Do you give corticosteroids in GBS?

NAHHHH not beneficial

17

How long does recovery take from GBS?

spontaneous recovery 3-4 weeks from sx onset

18

3 features that predict poor outcome in GBS?

-CN involvement
-intubation
-maximum disability at the time of initial presentation