Gut Microbiota in Health & Diseas Flashcards Preview

Yr2 Alimentary > Gut Microbiota in Health & Diseas > Flashcards

Flashcards in Gut Microbiota in Health & Diseas Deck (12)
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1
Q

Define Dysbiosis

A

A term for microbial imbalance or maladaptation on or inside the body such as an impaired microbiota

2
Q

Is dysbiosis of the gut microbiota a cause or correlation of disease?

A

Dysbiosis of the gut microbiota can be the cause of illness if you are unable to properly process your diet or get an infection.

It can also be the result of an illness, antibiotics and diet changes.

Essentially, changes in gut microbiota composition may be associated with diseases but this not always mean they cause the disease

3
Q

FOR THE RECORD

A

Im really confused about what were supposed to learn from these lectures so if any one has better notes use those :) also plz help

4
Q

Name some diseases that correlate with microbial dysbiosis?

A
IBS
IBD
Colerectal Cancer
Diabetes
Cardiovascular Disease
Rheumatoid Arthritis
Allergies
5
Q

Define probiotic?

A

Live microorganisms that when administered in correct amounts confer a health benefit on the host

6
Q

Define prebiotic?

A

Selectively fermented food that results in specific changes in the GI microbiota’s composition or activity thus conferring health benefits

(Specific bacteria food)

7
Q

How could probiotics be used to treat disease?

A
  • Competition (exclusion or direct antagonism)
  • Bioconversion of dietary compounds
  • Vitamin production
  • Barrier Function
  • Reduce inflammation
  • Stimulate the immune system
8
Q

Why would the effect of probiotics vary by person?

A

The persons own gut microbiota and genotype affects how the probiotics will grow and the effect they’ll have

9
Q

When would prebiotics be useful?

A

When you need to stimulate growth in certain commensal/beneficial bacteria

E.g. to cause:

  • Improved Gut Function, stool bulking & faster gut transit
  • reducing inflammatory markers to manage IBD
  • reduce risk of colon cancer
  • Some increase Ca absrption & bone health
10
Q

How does a FMT work for treating C. Diff?

A

Faecal sample from healthy donor transplanted into the recipient by enema, colonoscopy, capsules or naso-enteric tube

Repopulates colon, displaces C. Diff, prevets reinfection

11
Q

Why does FMT work for treating infection but not other GI diseases?

A

FMT works by restoring natural gut microbiota, any GI disease that doesnt work by altering the microbiota or infecting the GI tract would’nt be affected by FMT

12
Q

Why arn’t antibiotics great for GI problems?

A

They kill many commensal bacteria that may be important for health, as well as pathogens