Gynaecology Flashcards
(46 cards)
what are the levels of LH+FSH and gonadotropins (oes+test) in hypogonadotropic hypogonadism?
low LH + FSH
low oestrogen + testosterone
causes of hypogonadotropic hypogonadism
abnormal functioning of hypothalamus or pituitary gland
eg hypopituitarism, damage, chronic conditions, kallman syndrome, prolactinoma
what is kallman syndrome?
genetic condition
causes hypogonadotropic hypogonadism
failure to start puberty
absent sense of smell
what are LH+FSH and gonadotropin levels in hypergonadotropic hypogonadism?
high FSH + LH
low gonadotropin levels
what is hypergonadotropic hypogonadism caused by?
damage to gonads eg torsion, cancer, mumps congenital absence of ovaries turners syndrome AIS CAH
what is congenital adrenal hyperplasia? what enzyme is deficient? what is inheritance pattern?
deficiency of 21-hydroxylase enzyme
AR inheritance
symptoms of congenital adrenal hyperplasia?
tall for age facial hair primary amenorrhoea deep voice early puberty
assessment of primary amenorrhoea
FBC, ferritin - anaemia UE - CKD anti TTG, anti EMA LH, FSH - hypo/hypergonadotropic hypogonadism TFT ILGF-1 - GH deficiency prolactin - hyperprolactinaemia testosterone - PCOS, AIS, CAH genetics - turners syndrome
management of primary amenorrhoea
depends on cause > weight gain, CBT > treat endocrine condition > pulsatile GnRH, COCP in HH > COCP in PCOS
what is androgen insensitivity syndrome? what is inheritance pattern? what are patients genetically? XX or XY?
cells can’t respond to androgens as there are no androgen receptor. extra androgens –> oestrogen
X linked recessive
XY
AIS features?
external female genitalia and breasts testes in inguinal canal / abdomen infertile primary amenorrhoea inguinal hernia
AIS hormone results - LH, FSH, testosterone, oestrogen
LH increased
FSH increased / normal
testosterone increased
oestrogen increased
management of AIS
bilateral orchidectomy (avoid testicular tumours)
oestrogen therapy
vaginal surgery
support and counselling
levels of testosterone in CAH + AIS?
increased testosterone
CAH pathophysiology?
no 21-hydroxylase enzyme
this enzyme converts progesterone into ald+cortisol.
extra progesterone –> testosterone
result = high test, low cortisol + aldosterone
CAH presentation
virilised genitalia (ambiguous) enlarged vlitoris primary amenorrhoea tall for age, deep voice, early puberty HYPERPIGMENTATION!!!!!(increased acth)
CAH treatment? key features?
hyperpigmentation
cortisol replacement - hydrocortisone
aldosterone replacement - fludrocortisone
corrective surgery
when to investigate secondary amenorrhoea?
if normally regular = 3-6 months
if irregular = 6-12 months
causes of primary amenorrhoea
kallman syndrome turners syndrome damage to pituitary - surgery, radiation hypopituitarism damage to gonads - surgery, mumps, torsion
causes of secondary amenorrhoea?
pregnancy menopause and premature ovarian failure contraception PCOS sheehan syndrome hypo/hyperthyroidism pituitary - tumours, failure excessive exercise, low body weight
investigations in secondary amenorrhoea
beta HCG LH, FSH prolactin TSH testosterone
management of secondary amenorrhoea
hormone replacement
if PCOS - medroxyprogesterone for 14d
what causes urge incontinence
overactive detrusor muscle
what causes stress incontinence
weak pelvic floor muscles