H2 Antihistamines

Question 1

what are the adverse effects of cimetidine

Answer 1

anti adrenergic action
rapid iv infusion : confusion, hallucinations, convulsions, bradycardia, arrhythmia

Question 2

what is meant by antiadrenergic action

Answer 2

increases plasma prolactin levels
inhibition of degradation of estradiol in the liver

Question 3

what does anti adrenergic action present as

Answer 3

gynaecomastia
impotence
loss of libido
sperm diseases

Question 4

what’s the other adverse effect

Answer 4

inhibits cytochrome p450 enzyme and reduces hepatic blood flow

Question 5

list the 6 uses of antihistamines

Answer 5

2nd line medication in peptic ulcers
nonnuclear dyspepsia
stress ulcer and erosive gastritis
gastroesophageal reflux disease
prophylaxis of aspiration pneumonia
urticaria

Question 6

what is nonnuclear dyspepsia characterized by

Answer 6

fullness of abdomen,pain,gas,bloating,nausea,early satiety

Question 7

what are stressful conditions which could precipitate stress ulcer/erosive gastritis

Answer 7

hepatic coma, severe burns and trauma, prolonged surgery, prolonged intensive care, renal failure