Haem

Question 1

Howell-Jolly Body

Answer 1

Hyposplenism

Question 2

Burr cells

Answer 2

Uraemia

Question 3

Heinz bodies

Answer 3

G6PD

Question 4

Pelger Huet cells (hyposeg neuts)

Answer 4

Myelodysplasia

Question 5

Hypersegmented neuts (Right shift)

Answer 5

Megaloblastic anaemia

Question 6

Schistocytes

Answer 6

MAHA

Question 7

Target cells (codocytes)

Answer 7

Hyposplenism, Fe def, Haemoglobinopathies

Question 8

Tear drop cell (Dactrocyte)

Answer 8

Myelofibrosis + dry or bloody BM tap

Question 9

Atypical Lymphocyte

Answer 9

EBV (infectious mononucleosis)

Question 10

Cabot rings

Answer 10

Megaloblastic anaemia

Question 11

Golf ball cells

Answer 11

HbH disease (1 working Hb alpha gene)

Question 12

APTT

Answer 12

Intrinsic pathway (Heparin)

Question 13

PT

Answer 13

Extrinsic pathway (Warfarin)

Question 14

Haemophilia A

Answer 14

FVIII def

Question 15

Haemophilia B

Answer 15

FIX def

Question 16

vWF clotting screen

Answer 16

N PT, Increased APTT, Increased Bleeding time, Decreased Ristocetin activity

Question 17

Pappenheimer bodies

Answer 17

Lead poisoning, Sideroblastic anaemia

Question 18

Glanzmann’s thrombasthenia

Answer 18

Mut in GlpIIa/IIIb

Question 19

Bernard-Soulier

Answer 19

Mut in GlpIb

Question 20

CML

Answer 20

BCR-Abl t(9:22)

Question 21

AML

Answer 21

Auer rods, t(15:17), Sudan Black B +ve

Question 22

CLL

Answer 22

Smudge cells

Question 23

Hairy cell leukaemia

Answer 23

TARP

Question 24

Adult T cell Lymphoma

Answer 24

HTLV1, Cloverleaf nuclei

Question 25

ALL

Answer 25

Sudan Black B -ve

Question 26

Acute promyelocytic leukaemia

Answer 26

CH14 inversion (q11:q32)

Question 27

Protein S deficiency

Answer 27

VTE due to persistence of FVa+VIIIa

Question 28

Large granular lyphocytic leukaemia

Answer 28

Azurophilic granules in cytoplasm

Question 29

Burkitt's lymphoma

Answer 29

Starry sky t(8:14)

Question 30

Hodgkin's lymphoma

Answer 30

Reed-Sternberg cells

Question 31

Mantle cell lymphoma

Answer 31

t(11:14)

Question 32

Follicular lymphoma

Answer 32

t(14:18) | Centrocytes, centroblasts

Question 33

Essential thrombocythaemia

Answer 33

Erythromyalgia (burning sensation, erythema, swelling) | Hypercellular BM w/ giant plt + megakaryocytes

Question 34

Donath Landsteiner Abs

Answer 34

Paroxysmal Cold Haemoglobinuria

Question 35

PNH Feats

Answer 35

Pancytopoenia New thrombus Haemolysis Ham's test

Question 36

MM diagnostic criteria

Answer 36

CRAB Sx + Paraproteinaemia >30g/L OR Clonal plasma cells >10% BM

Question 37

Smouldering myeloma

Answer 37

Serum paraprotein >30g/L or Clonal plasma cells >10% BM + NO CRAB

Question 38

MGUS

Answer 38

Serum paraprotein less than 30g/L + Clonal Plasma cells less than 10% + No CRAB

Question 39

TTP feat

Answer 39

``` MARCH w/ low platelets MAHA A fever Renal failure CNS signs (fluctuating) Haematuria/proteinuria ```

Question 40

Hypocellular BM

Answer 40

Aplastic Anaemia

Question 41

Test for Sickle cell

Answer 41

Sodium Metabisulphite

Question 42

Causes of cold AIHA

Answer 42

COLD LID Lymphoproliferative disorders (CLL, Lymphoma) Infection (Mycoplasma, EBV) Do not Know