Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Learning Points Path > Haem > Flashcards

Haem Flashcards

(50 cards)

Start Studying
1
Q

Target cells

A

Hyposplenism, thalassaemia, IDA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Target INR

1st episode DVT/PE
AF
Recurrent DVT/PE
Mechanical valve

A

1st episode DVT/PE: [2.5]
AF: [2-3]
Recurrent DVT/PE: [3.5]
Mechanical valve: [2.5-3.5]

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Types of amyloid and association

A

AL: associated with multiple myeloma
AA: associated with chronic inflammatory disease e.g. `RA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Rouleux sign

A

Myeloma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is TTP? How might it present? What might you see on blood film?

A

Thrombotic thrombocytopenia purpura

The Terrible Pentad:
Fever
Neuro signs
Renal problems
Anaemia
Platelets

Blood film: schistocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which type of Hodgkin’s lymphoma carries the best prognosis?

A

lymphocyte predominant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Hb NR

A

For men, 13.5 to 17.5 g/dL

For women, 12.0 to 15.5 g/dL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Protein S deficiency results in impaired degradation of what factors?

A

Factors 5a and 8a

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Micromegakaryocytes

A

Found in myelodysplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

AIHA after mycoplasma or EBV infection

A

Cold Agglutinin Disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Types of paraproteinaemia

A

Myelomas (MGUS, smouldering myeloma, myeloma) and
Waldenstrom’s Macroglobinaemia
Systemic Amyloidosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

4 infectious causes of NHL?

A

EBV (Burkitts), H. pylori (MALT), coeliac (EALT), HTLV1 (Adult t cell lymphoma)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

donath landsteiner antibodies

A

paroxysmal cold haemoglobinuria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Intrinsic pathway factors

A

12, 11, 9, 8, 10

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Days after transfusion, jaundice and fever

A

Delayed haemolytic reaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Creatinine NR

A

♂ 59–104 μmol/ L

♀ 45–84 μmol/ L

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

At what INR would you give Vit K? What would you do with the warfarin?

A

> 5; stop warfarin, give vit K

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

physiological changes of pregnancy

A

platelets fall, plasma increases, MCV increases

Factors 7, vWF and fibrinogen all increase

Protein S falls

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Most common type of Hodgkin’s lymphoma

A

nodular sclerosing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Pancytopenia with skeletal abnormalities, renal malformations, short stature, skin pigmentation

A

Fanconi’s anaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

morning haemoglobinuria, thrombosis

Study These Flashcards
A

paroxysmal nocturnal haemoglobinuria

22
Q

Thalassaemia intermedia

23
Q

Normal bleeding time, normal or prolonged APTT, low factor 8

24
Q

Cabot rings

Study These Flashcards
A

megaloblastic anaemia

25
Auer rod + PML RARA fusion gene
Acute promyelocytic leukaemia
26
Ring sideroblasts
Myelodysplastic syndromes, refractory anaemias
27
Haemophilia A
Factor 8 deficiency; normal APTT | X linked recessive
28
Extrinsic pathway factors
7, 5
29
Skull bossing, maxillary hypertrophy, hairs on end skull x-ray
Beta thalassaemia
30
Urea NR
2.5 – 7.8 mmol/L
31
Enzyme controlling urea levels
HGPRT
32
Pseudo-Pelger Huet anomaly
aka Hyposegmented neutrophils Found in myelodysplasia
33
AIHA found in lymphoproliferative disorders, drugs, autoimmune disorders
Warm AIHA
34
IgM paraprotein plus visual disturbance
Waldenstrom's
35
paroxysmal nocturnal haemoglobinuria test?
Ham's test
36
Immediately post transfusion: rash, bloody diarrhoea, jaundice
GVHD
37
HUS? What signs? Cause?
Haemolytic uraemia syndrome High bleeding time, high creatinine, schistocytes Toxin mediated (e.g. bloody diarrhoea from E. Coli)
38
MOA of heparin?
Potentiates antithrombin III, which inactive thrombin and factors 9, 10 and 11
39
Vitamin K dependent factors
2, 7, 9, 10
40
prolonged bleeding time, normal or prolonged APTT, low factor 8
vWD
41
Clover leaf nuclei
Adult T cell lymphoma
42
Basophilic stippling
Thalassaemia trait, alcoholism
43
tear drop poikolocytes
myelofibrosis
44
Antidote to heparin?
Protamine sulphate
45
Richter's transformation; what is it and how might it present?
transformation of B cell chronic lymphocytic leukemia (CLL) or hairy cell leukemia into a fast-growing diffuse large B cell lymphoma, a variety of non-Hodgkin lymphoma Present with endobronchial mass, haemoptysis
46
Tartrate resistant acid phosphatase
Hairy cell leukaemia
47
Bleeding from mucous membranes
vWD
48
massive SM, low plt, low red cells, normal WCC
myelofibrosis
49
Japanese, caribbean, HTLV-1
Adult T cell leukaemia/lymphoma
50
17p deletion
bad prognosis in CLL

Learning Points Path (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions