Haem/ Onc Flashcards
(26 cards)
Bleomycin SE
Lung fibrosis
Doxorubicin (Anthracycline) SE
Cardiomyopathy
Vincristine SE
Peripheral neuropathy
Docetaxel SE
Neutropenia
Antiphospholipid in pregnancy Mx
LMWH (Dalteparin) + Aspirin
Wells score 2 or more Mx
DVT Likely
- USS <4hrs
- If >4hrs for interim anticoagulation
- if +ve, for anticoagulation
- if -ve, for D Dimer
- if D Dimer +ve - repeat USS in 1 week
Wells score 1 or less
DVT Unlikely
-D Dimer <4hrs
- if >4hrs for interim anticoagulation
- if +ve, for USS <4hrs (if >4hrs for anticoag)
Spinal cord compression earliest and most common sign
back pain
G6PD deficiency contraindications
Sulpha drugs - Sulphonamides, Sulfasalazine, Sulfonylureas
Primaquine (antimalrial)
Ciprofloxacin
- trigger haemolysis
Sickle cell vaccinations
pneumococcal every 5 years
CA 15-3 association
breast ca
Cyclophosphamide SE
Haemorrhagic cystitis
Sickle cell crisis - Thrombotic crisis Fx
“painful or vaso occlusive” crisis
precipitated by infection, dehydration, deoxygenation (eg high altitude)
- Pain
Sickle cell crisis - Aplastic crisis Fx
caused by parovirus
sudden fall in Hb
LOW reticulocyte
Sickle cell crisis - Sequestration crisis Fx
anaemia and RAISED reticulocyte
pooling of blood in organs - splenomegaly
Drug induced pancytopenia causes
cytotoxics
antibiotics: trimethoprim, chloramphenicol
anti-rheumatoid: gold, penicillamine
carbimazole*
anti-epileptics: carbamazepine
sulphonylureas: tolbutamide
VTE increased risk drugs
COCP
HRT - combined > oestrogen only
Raloxifen/ Tamoxifen
Antipsychotics eg olanzepine
Most common thrombophillia
Factor V leiden
Lymphoma Fx
Unresolving unexplained lymph nodes
itchiness
fever, night sweats, shortness of breath, pruritus and weight loss.
Elderly person with lymphocytosis
Chronic Lymphocytic leukaemia
haemophilia A lacks what clotting factor
Factor VIII
prolonged APTT
Haemophilia B (Christmas disease) lacks what clotting factor
Factor IX
prolonged APTT
Post splenectomy prophylactic abx
Phenoxymethylpenicillin (for 2 years)
Polycythaemia ruba vera Fx
Bleeding, bruising
low grade fever, tired, night sweats, weight loss
Pruritis (esp in warm bath)
