Haem Q's Flashcards
(14 cards)
Haem complications of SLE
pancytopenia 2o to immune mediated peripheral destruction
Heparin induced thrombocytopenia
- occurs 5-10/7 after starting unfractionated heparin
*thrombocytopenia (30,000-60,000)
*thrombosis (arterial or venous)
*due to antibodies against PLT factor 4
*prolonged aPTT
tumor lysis syndrome
- occurs after chemotherapy
- high uric acid, potassium and Po4
*hypocalcaemia
*acute kidney injury, arrhythmias, seizures
*mgx:- rasburicase (recombinant urate oxidase)
prophylaxis pre chemo- allopurinol. febuxostat
TTP
pentad of
*MAHA
*fever
*renal insufficiency
*thrombocytopenia
*neurologic changes
2o ADAMST13 deficiency
coagulation normal
mgx:- plasma exchange
ondansetron MOA
5HT 3 antagonist
first line for chemo related N+V
causes of ant mediastinal mass
5 T’s
*thymoma
*thyroid
*Terrible lymphoma
*teratoma
*thoracic aorta
Hodgkin’s lymphoma
*B symptoms
*peripheral or mediastinal lymphadenopathy
*alcohol induced pain in areas of lymphadenopathy
*pruritis
*compressive symptoms ( sob, cough, retrosternal pain)
*elevated LDH and eosinophilia
*reed sternberg cells
megaloblastic anaemia
MCV >100
other features:- hypersegmented neutrophils, anisocytosis, poikilocytosis, basophilic stippling.
*initial test is for B12 and folate levels
Hodgkin’s lymphoma how to confirm diagnosis
lymph node biopsy –> Reed Sternberg cells
PET scan to stage disease
BCR-ABL1 assoc with which disease
CML
aplastic anaemia
*pancytopenia due to a acquired multipoint stem cell damage
*absent splenomegaly
*morphologially normal cells
2 common causes of microcytic anaemia and how to differentiate between them
iron def anaemia and thalassemia
*either by iron studies or no reponse to iron treatment after 4/52
chronic disseminated intravascular coagulation
*assoc with mucin producing malignancy (pancreatic, gastric, breast, ovarian)
*symptoms of bleeding –>mucocutaneous bleeding and thromboembolic events arterial/venous
* normal coagulation and bleeding times
