Haematological changes in systemic disease

Question 1

What is anaemia of chronic disease?

Answer 1

Anaemia caused by chronic inflammation such as rheumatoid arthritis, inflammatory bowel disease (e.g. crohn’s) and chronic infections (e.g. TB)

Question 2

What are 3 contributing factors of anaemia of chronic dysfunction?

Answer 2

1) Iron dysfunction
2) Lack of response to EPO in BM
3) Reduced lifespan

Question 3

What is functional iron deficiency?

Answer 3

When there is sufficient iron in the body but not available to the developing erythroid cells