Haematology

Question 1

translocation seen in burkitts

Answer 1

c-myc

Question 2

traetment for antiphospholipid syndrome in pregnancy

Answer 2

LMWH + aspirin

Question 3

cells seen in G6PD

Answer 3

bite and blister

Question 4

what is richters transformation

Answer 4

CLL transforming into high grade NHL

Question 5

syndrome seen with burkitts

Answer 5

tumour lysis syndrome

Question 6

treatment for PCV

Answer 6

venesect to haematocrit <0.45
aspiring
hydroxycarbamide

Question 7

mutation in PCV

Answer 7

JAK2

Question 8

how long does a non urgent transfusoin take

Answer 8

90-120 mins

Question 9

treatment for ITP

Answer 9

oral prednisolone

Question 10

DIC typical blood picture

Answer 10

derceased platelts + fibrinogen
increased PT, APTT and fibrinogen degredation products

Question 11

progression of PCV

Answer 11

myelofibrosis or AML

Question 12

cells seen in CLL

Answer 12

smudge / smear cells

Question 13

which transfusions have the higher risk of bacterial contamination

Answer 13

platelet

Question 14

what happens to reticulocytes in aplastic crisus

Answer 14

decrease

Question 15

what happens to reticulocytes in sequestrian crisis

Answer 15

increase

Question 16

when are haemarthroses seen

Answer 16

haemophilia

Question 17

how to treat neutropenic sepsis

Answer 17

tazocin + piperacillin

Question 18

cells seen in DIC

Answer 18

schistocytes

Question 19

starry nigth

Answer 19

burkitts

Question 20

pain on alcohol consumption

Answer 20

hodgkins

Question 21

reed sternberg cells

Answer 21

hodgkins

Question 22

bence jones proteins

Answer 22

multiple myeloma

Question 23

how to treat multiple myeloma

Answer 23

vinecristine + Adriamycin + dexamethasone

Question 24

how to manage bleeding on warfarin

Answer 24

vit K

Question 25

signs of tumour lysis syndrome

Answer 25

hyperkalaemia

Question 26

IgG seen in which time of haemolysis

Answer 26

warm

Question 27

CML treatment

Answer 27

imantinib

Question 28

neonatal features of G6PD

Answer 28

jaundice

Question 29

genes in sickle cell trait

Answer 29

HbAs

Question 30

deficiency in TTP

Answer 30

ADAMTs-13

Question 31

treatment of warm autoimmune anaemia

Answer 31

steroids

Question 32

cause of agranulocytosis

Answer 32

clozapine

Question 33

when is cold IgM seen

Answer 33

1-3 weeks post infectoin

Question 34

which mechanism does dabigatran have

Answer 34

direct thrombin inhibitor

Question 35

iron deficiency anaemia blood picture

Answer 35

decreased iron and ferritin, increased TIBC and transferrin

Question 36

isolated thrombocytopenia

Answer 36

ITP

Question 37

aplstic crisis cause

Answer 37

parovirus B12

Question 38

howel jolly bodies

Answer 38

coeliac

Question 39

prophylaxis of neutropenic sepsis

Answer 39

fluoroquinolone

Question 40

worst prognosis of HL

Answer 40

lymphocyte depleted

Question 41

most common HL

Answer 41

nodular sclerosis

Question 42

causes of microcytic anaemia

Answer 42

iron deficiency anaema of CD thalassaemia sidero-blastic

Question 43

causes of normocytic anaemia

Answer 43

blood loss anaemia of CD haemoysis anaplastic anaemia CKD hypothyroid

Question 44

causes of macrocytic anaemia

Answer 44

megaloblastic - B12, foalte, hyperpigmented neutrophils normoblastic - alcohol, liver dsease, reticulocytosis, myelodysplasia, hypothyroidism

Question 45

when is cryoprecipitte used

Answer 45

DIC, liver failure, hypofibringogenaemia secondary to massive transfusion

Question 46

what is cryoprecipiatate a source of

Answer 46

factors VIII and fibrinogen

Question 47

where is B12 absorbed

Answer 47

terminal ileum via cubulin receptors

Question 48

where is folate absorbed

Answer 48

jejunum / duodenum

Question 49

which cells are seen in nodular sclerosing HL

Answer 49

lacunar

Question 50

staging for HL

Answer 50

ann arbor

Question 51

symptoms of acute haemolytic reaction

Answer 51

pyrexia, hypotension, flushing, abdo pain within 24 hours (usually immediately)

Question 52

symptoms of febrile non haemolytic reactions

Answer 52

fever but no haemolysis

Question 53

sympotms of TACO

Answer 53

hypertensive, fluid overload, pulmonary oedema

Question 54

symptoms of anaphylaxis

Answer 54

urticaria