Haematology Flashcards
(38 cards)
What is the problem with prescribing topical miconazole to a patient who is taking Warfarin ?
Potentiating bleed risk.
For a patient with moderate haemophilia, is factor cover required for supragingival scaling ?
No.
What factors does prothrombin time test (PT) measure ?
VIII, IX, XII, X, V, prothrombin and fibrinogen.
A patient has an elevated prothrombin time, what does this indicate ?
Bleeding tendency - higher INR.
INR can be calculated from what test value ?
Prothrombin time test.
A patient has liver disease and another is taking warfarin, what blood test will come back deranged ?
Prothrombin time test.
What factors does activated partial thromboplastin time test (aPTT) measure ?
VII, X, V, prothrombin and fibrinogen.
What is the difference between aPTT and PT tests ?
PT - more extensive testing, shows levels of more factors compared to APTT.
PT - time that it takes plasma to clot after the addition of phospholipid, tissue factor (factor III), and calcium.
aPTT - time it takes plasma to clot after the addition of a contact agent that fully activates factors XI, calcium and phospholipids.
Patient has haemophilia A, what blood test will come back deranged ?
Activated partial thromboplastin time test.
Is augmentation of factor levels required for patient with mild haemophilia A ?
Yes.
Is augmentation of factor levels required for patient with Type 3 VW disease ?
Yes.
Is augmentation of factor levels required for patient with Type 2a VW disease ?
Yes.
Is augmentation of factor levels required for patient with moderate haemophilia B ?
Yes.
How is Type 2 VW disease managed ?
With Factor VIII concentrate.
What is haemophilia A associated with ?
Factor VIII deficiency.
Is a single tooth extraction high or low risk ?
Low.
Between what values is normal clotting factor % for patient with moderate Haemophilia A ?
1-5%
What are the possible causes of microcytic anaemia ?
Iron deficiency, thalassemia.
How is microcytic anaemia diagnosed from blood test results ?
Low MCV (less than 83 micron 3)
Define microcytic anaemia.
Smaller RBC than normal due to lack of haemoglobin production.
What are the possible causes of microcytic anaemia ?
Vit B12 and folate deficiency or retics.
Define macrocytic anaemia.
Larger RBC than normal due to decreases DNA synthesis.
How is macrocytic anaemia diagnosed from blood test results ?
(MCV) greater than 100 fL.
What is normocytic anaemia caused by ?
Haemorrhage - GI bleed, trauma etc.
