Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

CRAM CARDS > haematology > Flashcards

haematology Flashcards

(62 cards)

Start Studying
1
Q

treatment for hodgkin’s lymphoma

A

chemotherapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

reed-sternberg cells

A

hodgkin’s lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

when to offer platelet transfusion in someone with clinically significant bleeding

A

platelet count of <30 x 10 9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

when to offer platelet transfusion in someone with clinically significant bleeding at critical sites such as CNS

A

maximum < 100 x 10 9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what blood product has the highest risk of bacterial contamination

A

platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

DOAC reversal agent

A

andexanet alfa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Howell-Jolly bodies

A

hyposplenism (reduced spleen function)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

hypersegmented neutrophils, oval macrocytes

A

megaloblastic macrocytic anaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

h.pylori and lymphoma

A

MALToma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

smear/smudge cells

A

CLL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

philadelphia chromosome

A

t(9:22)
CML

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

treatment for CML

A

imatnib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

aquagenic puritis

A

polycythaemia vera

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

auer rods

A

AML

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

BCR-ABL1 positive myeloproliferative neoplasms

A

CML

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

BCR-ABL1 negative myeloproliferative neoplasms

A

polycythaemia vera
essential thrombocytopenia
primary myelofibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

gene associated with polycythaemia vera

A

JAK2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

treatment of polycythaemia vera

A

chemotherapy (hydroxycarbamide)
venesection
aspirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what is essential thrombocythaemia

A

myeloproliferative neoplasm causing increased number of platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

what is polycythaemia vera

A

myeloproliferative neoplasm causing increased number of RBCs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

prognosis in myeloproliferative diseases

A

uncurable
PV: The 5 year survival rate for PV patients is 85%

ET: The 5 year survival is equivalent to matched, healthy people

Primary myelofibrosis: at 5 years, the survival rate is 55% (median survival is 4-5 years)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

blood film in primary myelofibrosis

A

leucoerythroblastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

treatment of primary myelofibrosis

A

supportive
JAK2 inhibitors (ruxolitinib)
allogenic stem cell
chemotherapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

blast crisis in CML

A

transformation to AML

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
primary myelofibrosis carries a risk of transformation to...
acute leukaemia
26
mild hypochromic, microcytic anaemia raised HbA2
beta-thalassaemia trait
27
mildy elevated APTT
von willebrands disease
28
itch without rash lymph node pain
hodgkin's lymphoma
29
typical age group for hodgkin's lymphoma
30s
30
B cell non-hodgkin's lymphoma monoclonal antibody
rituximab CD20
31
T cell non-hodgkin's lymphoma monoclonal antibody
rentuximab CD30
32
which types of NHL are curable
high grade are potentially curable low grade are incurable but patients may not need treatment
33
CLL can transform to...
high grade NHL
34
types of low grade NHL
CLL MALToma (mantel zone) marginal zone follicular
35
follicular NHL is associated with what chromosome
t(14:18)
36
types of high grade lymphoma
diffuse large b cell lymphoma burkitt's lymphoma
37
virus associated with burkitt's lymphoma
EBV
38
chromosome associated with burkitt's lymphoma
t(8:14) --> c-mcy
39
what drug are an integral part of lymphoma management
steroids
40
thrombocytopenia
low platelets
41
thrombocytosis
high platelets
42
first line management of immune thrombocytopenia
oral prednisolone
43
full blood count: isolated thrombocytopenia
ITP
44
definition of acute leukaemia
proliferation of abnormal progenitors WITH block in differentiation/maturation
45
definition of chronic leukaemia
proliferation of abnormal progenitors WITHOUT block of differentiation/maturation
46
diagnostic test for CML
FBC and immunophenotyping
47
associations with AML
gum hypertrophy auer rods DIC
48
associations with ALL
cranial nerve palsies common in children testicular enlargement
49
in which conditions is APTT raised but as an artifact
antiphospholipid syndrome
50
Microcytic hypochromic red cells with mild anaemia
alpha thalassaemia trait
51
HbH inclusions
HbH disease (type of alpha thalassaemia) Only one working alpha gene per cell
52
Hb Barts hydrops fetalis features
incompatible with life (most die in-utero) Excess B chains form tetramers (B4) = HbH Excess y chains form tetramers (y4) = Hb Barts
53
features of B thalassaemia major
can't make adult haemoglobin Presents age 6-24mnths as HbF falls Extramedullary haematopoiesis causing: hepatosplenomegaly, skeletal changes (marrow expands), organ damage lifelong transfusion dependency
54
what transfusion reaction causes a positive direct antiglobulin test
delayed haemolytic transfusion reaction
55
in a non-urgent scenario what time period should a unit of RBCs be transfused over
90-120 mins
56
Factor V Leiden mutation causes...
activated protein C resistance
57
most common inherited thrombophilia
Activated protein C resistance (Factor V Leiden)`
58
blood findings in anaemia of chronic disease
A normocytic anaemia with low serum iron, low TIBC but raised ferritin in a patient with a chronic illness
59
Platelet transfusion for surgery if...
< 50×109/L for most patients 50-75×109/L if high risk of bleeding >100×109/L if surgery at critical site
60
when is irradiated blood required
severe immunodeficiency
61
to diagnosis tumour lysis syndrome...
you require either increased serum creatinine, a cardiac arrhythmia or a seizure to have occurred
62
Bite and blister cells
G6PD deficiency

CRAM CARDS (21 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions