Haematology Flashcards
1
Q
What Ig is warm AIHA almost always due to?
A
IgG
2
Q
Which Ig is cold AIHA (cold agglutinin) disease usually due to?
A
IgM
3
Q
How do the antibodies in warm AIHA destroy red cells?
A
By binding to Fc receptor on phagocytes. Occurs most effectively in the spleen.
4
Q
What is the first line agent in treating warm AIHA?
A
Glucocorticoids
5
Q
What are the usual second line agents in treating warm AIHA?
A
Splenectomy or Rituxumab (also Danazol and cytotoxic agents)
