Haematopoiesis, haematology, haemostasis (year 2) Flashcards
(189 cards)
define haematopoiesis
production of blood cells
what tissue type are leucocytes, erythrocytes and platelets produced in?
haemopoietic tissue
where is the major site of haematopoiesis?
bone marrow
what blood cell has the longest lifespan?
erythrocytes
what is the average lifespan of an RBC?
1-5 months
how long is platelets lifespan?
10 days
how long do leucocytes live for?
hours to years depending on the type
what blood cells have the shortest lifespan?
neutrophils
what is the first thing that is noticed when there is a sudden arrest of haematopoiesis?
reduction in neutrophils (neutropenia)
where is the best site to collect bone marrow in dogs?
head of femur and humerus
what cells do all blood elements arise from?
stem cells
what are the types of stem cells?
totipotent
pluripotent
multipotent
unipotent
define totipotents
stem cells that are present in the embryo and can divide into any cell
define pluripotent
stem cells found in the blastocyst that can differentiate into almost all cells but not into an embryo
define multipotent
stem cell found in most tissues that can differentiate into a limited range of cells such as haematopoitic stem cells
define unipotent
stem cells that can only generate one type of cell
what can a multipoint haematopoietic stem cell differentiate into?
common myeloid progenerator
common lymphoid progenitor
name some cells that the common myeloid progenerator may differentiate into
erythrocytes
mast cells
megakaryocytes
myeloblast - basophil, eosinophil, monocyte, neutrophil
what can common lymphoid progenitor cells differentiate into?
NK cells
lymphocytes
what is lymphogenesis?
lymphocyte production
where does lymphogenesis being?
bone marrow
where do the later stages of lymphocyte maturation, proliferation and migration occur?
lymphoid organs
in a steady state in bone marrow which pool is expected to dominate?
maturation and storage
does granulopoiesis or monocytopoiesis occupy the majority of the haematopoetic tissue?
granulopoiesis