Haemodynamic Disorders

Question 1

What are the three main causes of thrombus formation

Answer 1

Endothelial injury
Abnormal blood flow
Hyper-coagulability

Question 2

Types of arterial thrombi

Answer 2

Mural thrombus = attached to blood vessel and doesn’t really block vessel
Occlusive thrombus = tends to occlude vessels and process is driven by platelets

Question 3

How does a plaque form

Answer 3

Formation of the fatty streak. Endothelial dysfunction allows accumulation of lipids. This results in leukocyte recruitment and formation of foam cells
Foam cells die and formation of lipid rich necrotic core occurs which continues to grow and is encapsulated by a fibrous cap
Plaque might rupture = thrombogenic potential

Question 4

Complications of atherosclerosis

Answer 4

Coronary artery disease
Carotid artery’s disease
Peripheral artery disease
- Chronic kidney disease
Aneurysm