Haemopoeisis Flashcards
1
Q
Role of the mature blood cells
A
2
Q
Which anatomical site is most appropriate for bone marrow biopsy in adults?
A
Sacrum
3
Q
Which anatomical site is most appropriate for bone marrow biopsy in children?
A
Tibia
4
Q
When is myeloid:erythroid ratio reversed?
A
Haemolysis
Acute blood loss (not chronic)
5
Q
What regulates haemopoiesis?
A
- Intrinsic properties of cells (e.g stem cells vs progenitor cells vs mature cells)
- Signals from immediate surroundings and the periphery (microenvironmental factors)
- Specific anatomical area (‘niche’) for optimal developmental signals
6
Q
Role of thrombopoietin
A
Thrombopoietin regulates growth and development of megakaryocytyes from their precursors
7
Q
What regulates neutrophil precursor maturation?
A
G-CSF (granulocyte-colony stimulating factor)
8
Q
How to assess haemopoiesis in non-lymphoid cells
A
Blood count and blood film
9
Q
How to assess haemopoeisis in lymphoid cells?
A
Immunophenotyping
- need to see the expression of antigens indicating lineage or stage of development
10
Q
A
