Haemotology

Question 1

Below which level of Hb is a transfusion often indicated

Answer 1

Hb <7g/dl

Question 2

SE of iron supplements

Answer 2

Constipation

Question 3

Causes of right shift of O2 dissociation curve

Answer 3

C02
Acidosis
Exercise
Temperature

Question 4

What binds to free Hb following haemolysis

Answer 4

Haptoglobin complexes with free Hb and this can then bind to macrophages allowing clearance and metabolism

Question 5

Examples of iron chelation agents

Answer 5

• Deferiprone
• Deferoxamine
• Deferasirox

Question 6

What is HbSC

Answer 6

*Where patients inherit one HbS and another abnormal Hb (HbC) resulting in a milder form of sickle cell disease (HbSC)

Question 7

Changes in FBC during pregnancy

Answer 7

RBCs (+Hb) increase by 20% but plasma has a 50% increase which results in apparent anaemia

Question 8

Which deficiency can follow from an ileocaecal resection

Answer 8

Vit B12 deficiency

Question 9

Describe the histological classification of Hodgkin’s lymphoma

Answer 9

• Nodular sclerosing (70%) - good prognosis, mc in women, associated with lacunar cells
• Mixed cellularity (20%) - good prognosis, large n.o Reed-Sternberg cells
• Lymphocyte predominant (5%) - BEST prognosis
• Lymphocyte depleted (rare) - WORST prognosis