Hallmarks of Cancer and Pharmaceutical Targets Flashcards
1
Q
Evading growth suppressors
A
CDK inhibitors
2
Q
Avoiding immune destruction
A
Immune activating anti-CTLA4 mAb
3
Q
Enabling replicative immortality
A
Telomerase inhibitors
4
Q
Tumor-promoting inflammation
A
Selective anti-inflammatory drugs
5
Q
Activating invasion and metastasis
A
Inhibitors of HGF/c-Met
6
Q
Inducing angiogenesis
A
Inhibitors of VEGF signaling
7
Q
Genome instability and mutation
A
PARP inhibitors
8
Q
Resisting cell death
A
Proapoptotic BH3 mimetics
9
Q
Deregulating cellular energetics
A
Aerobic glycolysis inhibitors
10
Q
MDM2 inhibitors
A
Indirectly brings back p53
11
Q
Ipilimumab
A
CTLA-4 inhibitor
12
Q
Pembrolizumab
A
Binds PD-1
13
Q
Imetelstat
A
Telomerase inhibitor
14
Q
Bevacuzimab
A
VEGF inhibition
15
Q
DNA-Damaging Drugs
A
Cell cycle dependent; alkylating agents, topoisomerase inhibitors, antibiotics
