HARR_2.1 Coagulation and Fibrinolytic Systems/Reagents and Methods Flashcards
(116 cards)
1
Q
Which of the following initiates in vivo coagulation by activation of factor VII?
A. Protein C
B. Tissue factor (TF)
C. Plasmin activator
D. Thrombomodulin (TM)
A
Tissue factor (TF)
2
Q
Which of the following clotting factors plays a role in clot formation in vitro, but not in vivo?
A. Factor VIIa
B. Factor IIa
C. Factor XIIa
D. Factor Xa
A
Factor XIIa
3
Q
The anticoagulant of choice for most routine coagulation studies is:
A. Sodium oxalate
B. Sodium citrate
C. Heparin
D. Ethylenediaminetetraacetic acid (EDTA)
A
Sodium citrate
4
Q
Which anticoagulant:blood ratio is correct for coagulation procedures?
A. 1:4
B. 1:5
C. 1:9
D. 1:10
A
1:9
5
Q
Which results would be expected for PT and APTT in a patient with polycythemia?
A. Both prolonged
B. Both shortened
C. Normal PT, prolonged APTT
D. Both normal
A
Both prolonged
6
Q
Which reagents are used in the PT test?
A. Thromboplastin and sodium chloride
B. Thromboplastin and potassium chloride
C. Thromboplastin and calcium
D. Actin and calcium chloride
A
Thromboplastin and calcium
7
Q
Which test would be abnormal in a patient with factor X deficiency?
A. PT only
B. APTT only
C. PT and APTT
D. Thrombin time (TT)
A
PT and APTT
8
Q
Which clotting factor is not measured by the PT and APTT tests?
A. Factor VIII
B. Factor IX
C. Factor V
D. Factor XIII
A
Factor XIII
9
Q
A modification of which procedure can be used to measure fibrinogen?
A. PT
B. APTT
C. TT
D. Fibrin degradation products
A
TT
10
Q
Which of the following characterizes vitamin K?
A. It is required for biological activity of fibrinolysis
B. Its activity is enhanced by heparin therapy
C. It is required for carboxylation of glutamate residues of some coagulation factors
D. It is made by endothelial cells
A
It is required for carboxylation of glutamate residues of some coagulation factors
11
Q
Which fragments of fibrin clot degradation are measured by the D-dimer test?
A. Fragments X and Y
B. Fibrinopeptide A and B
C. Fragments D and E
D. The D-D domains
A
The D-D domains
12
Q
Which of the following clotting factors are measured by the APTT test?
A. Factors II, VII, IX, X
B. Factors VII, X, V, II, I
C. Factors XII, XI, IX, VIII, X, V, II, I
D. Factors XII, VII, X, V, II, I
A
Factors XII, XI, IX, VIII, X, V, II, I
13
Q
Which coagulation test(s) would be abnormal in a patient with vitamin K deficiency?
A. PT only
B. PT and APTT
C. Fibrinogen level
D. TT
A
PT and APTT
14
Q
Which of the following is correct regarding the international normalized ratio (INR)?
A. It uses the international sensitivity ratio (ISR)
B. It standardizes PT results
C. It standardizes APTT results
D. It is used to monitor heparin therapy
A
It standardizes PT results
15
Q
Which of the following is referred to as an endogenous activator of plasminogen?
A. Streptokinase
B. Transamidase
C. Tissue plasminogen activator (tPA)
D. tPA inhibitor
A
Tissue plasminogen activator (tPA)
16
Q
Which protein is the primary inhibitor of the fibrinolytic system?
A. Protein C
B. Protein S
C. α2-Antiplasmin
D. α2-Macroglobulin
A
α2-Antiplasmin
17
Q
Which of the following statements is correct regarding the D-dimer test?
A. Levels are decreased in DIC
B. Test detects polypeptides A and B
C. Test detects fragments D and E
D. Test has a negative predictive value
A
Test has a negative predictive value
18
Q
A protein that plays a role in both coagulation and PLT aggregation is:
A. Factor I
B. Factor VIII
C. Factor IX
D. Factor XI
A
Factor I
19
Q
A standard 4.5-mL blue-top tube filled with 3.0 mL of blood was submitted to the
laboratory for PT and APTT tests. The sample is from a patient undergoing surgery the
following morning for a tonsillectomy. Which of the following is the necessary course of
action by the medical laboratory scientist?
A. Run both tests in duplicate and report the average result
B. Reject the sample and request a new sample
C. Report the PT result
D. Report the APTT result
A
Reject the sample and request a new sample
20
Q
Which statement is correct regarding sample storage for the PT test?
A. Stable for 24 hours if the sample is capped
B. Stable for 24 hours if the sample is refrigerated at 4°C
C. Stable for 4 hours if the sample is stored at 4°C
D. Should be run within 8 hours
A
Stable for 24 hours if the sample is capped
21
Q
In primary fibrinolysis, the fibrinolytic activity results in response to:
A. Increased fibrin formation
B. Spontaneous activation of fibrinolysis
C. Increased fibrin monomers
D. DIC
A
Spontaneous activation of fibrinolysis
22
Q
Plasminogen deficiency is associated with:
A. Bleeding
B. Thrombosis
C. Increased fibrinolysis
D. Increased coagulation
A
Thrombosis
23
Q
Which of the following clotting factors are activated by thrombin that is generated by
tissue pathway (TF-VIIa)?
A. Factors XII, XI
B. Factors XII, I
C. Factors I, II
D. Factors V, VIII
A
Factors V, VIII
24
Q
Which substrate is used in a chromogenic factor assay?
A. p-nitroaniline (pNa)
B. Chlorophenol red
C. Prussian blue
D. Ferricyanide
A
p-nitroaniline (pNa)
25
Which substrate is used in a chromogenic factor assay?
A. p-nitroaniline (pNa)
B. Chlorophenol red
C. Prussian blue
D. Ferricyanide
p-nitroaniline (pNa)
26
Which of the following antibodies is used in the D-dimer assay?
A. Polyclonal antibody directed against X and Y fragments
B. Polyclonal antibody directed against D-dimer
C. Monoclonal antibody against D and E fragments
D. Monoclonal antibody against D-dimer
Monoclonal antibody against D-dimer
27
Thrombotic thrombocytopenic purpura (TTP) is characterized by:
A. Prolonged PT
B. Increased PLT aggregation
C. Thrombocytosis
D. Prolonged APTT
Increased PLT aggregation
28
Thrombocytopenia may be associated with:
A. Splenectomy
B. Hypersplenism
C. Acute blood loss
D. Increased proliferation of pluripotent stem cells
Hypersplenism
29
Aspirin prevents PLT aggregation by inhibiting the action of which enzyme?
A. Phospholipase
B. Cyclo-oxygenase
C. Thromboxane A2 (TXA2) synthetase
D. Prostacyclin synthetase
Cyclo-oxygenase
30
Normal PLT adhesion depends on:
A. Fibrinogen
B. Glycoprotein Ib
C. Glycoprotein IIb–IIIa complex
D. Calcium
Glycoprotein Ib
31
Which of the following test results is normal in a patient with classic von Willebrand
disease?
A. PLT aggregation
B. APTT
C. PLT count
D. Factor VIII:C and von Willebrand factor (VWF) levels
PLT count
32
Bernard–Soulier syndrome is associated with:
A. Decreased factor IX
B. Decreased factor VIII
C. Thrombocytopenia and giant PLTs
D. Abnormal PLT function test results
Thrombocytopenia and giant PLTs
33
When performing PLT aggregation studies, which set of PLT aggregation results would
most likely be associated with Bernard–Soulier syndrome?
A. Normal PLT aggregation to collagen, adenosine diphosphate (ADP), and ristocetin
B. Normal PLT aggregation to collagen, ADP, and epinephrine (EPI); decreased aggregation to ristocetin
C. Normal PLT aggregation to EPI and ristocetin; decreased aggregation to collagen and ADP
D. Normal PLT aggregation to EPI, ristocetin, and collagen; decreased aggregation to ADP
Normal PLT aggregation to collagen, ADP, and epinephrine (EPI); decreased aggregation to ristocetin
34
Which set of PLT responses would be most likely associated with Glanzmann thrombasthenia?
A. Normal PLT aggregation to ADP and ristocetin; decreased aggregation to collagen
B. Normal PLT aggregation to collagen; decreased aggregation to ADP and ristocetin
C. Normal PLT aggregation to ristocetin; decreased aggregation to collagen, ADP, and EPI
D. Normal PLT aggregation to ADP; decreased aggregation to collagen and ristocetin
Normal PLT aggregation to ristocetin; decreased aggregation to collagen, ADP, and EPI
35
Which of the following is a characteristic of acute immune thrombocytopenic purpura?
A. Spontaneous remission within a few weeks
B. Predominantly seen in adults
C. Nonimmune PLT destruction
D. Insidious onsent
Spontaneous remission within a few weeks
36
TTP differs from DIC in that:
A. APTT is normal in TTP but prolonged in DIC
B. Schistocytes are not present in TTP but are present in DIC
C. PLT count is decreased in TTP but normal in DIC
D. PT is prolonged in TTP but decreased in DIC
APTT is normal in TTP but prolonged in DIC
37
Several hours after birth, a baby boy develops petechiae and purpura and hemorrhagic diathesis. The PLT count is 18 × 109/L. What is the most likely explanation for the low
PLT count?
A. Drug-induced thrombocytopenia
B. Secondary thrombocytopenia
C. Neonatal alloimmune thrombocytopenia
D. Neonatal DIC
Neonatal alloimmune thrombocytopenia
38
12. Which of the following is associated with post-transfusion purpura (PTP)?
A. Nonimmune thrombocytopenia/alloantibodies
B. Immune-mediated thrombocytopenia/alloantibodies
C. Immune-mediated thrombocytopenia/autoantibodies
D. Nonimmune-mediated thrombocytopenia/autoantibodies
Immune-mediated thrombocytopenia/alloantibodies
39
Hemolytic uremic syndrome (HUS) is associated with:
A. Fever, thrombocytosis, anemia, and renal failure
B. Fever, granulocytosis, and thrombocytosis
C. Escherichia coli 0157:H7
D. Leukocytosis and thrombocytosis
Escherichia coli 0157:H7
40
Storage pool deficiencies are defects of:
A. PLT adhesion
B. PLT aggregation
C. PLT granules
D. PLT production
PLT granules
41
Lumi-aggregation measures:
A. PLT aggregation only
B. PLT aggregation and adenosine triphosphate (ATP) release
C. PLT adhesion
D. PLT glycoprotein Ib
PLT aggregation and adenosine triphosphate (ATP) release
42
Neurological findings may be commonly associated with which of the following disorders?
A. HUS
B. TTP
C. ITP
D. PTP
TTP
43
Which of the following is correct regarding acquired TTP?
A. Autoimmune disease
B. Decreased VWF
C. Decreased PLT aggregation
D. Decreased PLT adhes
Autoimmune disease
44
Hereditary hemorrhagic telangiectasia is a disorder of:
A. PLTs
B. Clotting proteins
C. Fibrinolysis
D. Connective tissue
Connective tissue
45
Which of the following prevents PLT aggregation?
A. TXA2
B. Thromboxane B2
C. Prostacyclin
D. Antithrombin (AT)
Prostacyclin
46
Which defect characterizes Gray syndrome?
A. PLT adhesion defect
B. Dense granule defect
C. Alpha granule defect
D. Coagulation defect
Alpha granule defect
47
The P2Y12 ADP receptor agonist assay may be used to monitor PLT aggregation
inhibition to which of the following drugs?
A. Warfarin
B. Heparin
C. Low-molecular-weight heparin (LMWH)
D. Clopidogrel (Plavix)
Clopidogrel (Plavix)
48
Which of the following instruments can be used to evaluate PLT function?
A. PLT aggregometer
B. VerifyNow
C. PFA-100
D. All of the above
All of the above
49
Which of the following PLT aggregating agents demonstrates a monophasic aggregation curve when used in the optimal concentration?
A. Thrombin
B. Collagen
C. ADP
D. EPI
Collagen
50
The APTT is sensitive to a deficiency of which clotting factor?
A. Factor VII
B. Factor X
C. PF3
D. Calcium
Factor X
51
Which test result would be normal in a patient with dysfibrinogenemia?
A. TT
B. APTT
C. PT
D. Immunologic fibrinogen level
Immunologic fibrinogen level
52
A patient with a prolonged PT is given intravenous vitamin K. PT is corrected to normal after 24 hours. Which clinical condition most likely caused these results?
A. Necrotic liver disease
B. Factor X deficiency
C. Fibrinogen deficiency
D. Obstructive jaundice
Obstructive jaundice
53
Which factor deficiency is associated with prolonged PT and APTT?
A. Factor X
B. Factor VIII
C. Factor IX
D. Factor XI
Factor X
54
Prolonged APTT is corrected with factor VIII–deficient plasma but not with factor IX–deficient plasma. Which factor is deficient?
A. Factor V
B. Factor VIII
C. Factor IX
D. Factor X
Factor IX
55
Which of the following is a characteristic of classic hemophilia A?
A. Abnormal PLT aggregation
B. Autosomal recessive inheritance
C. Mild to severe bleeding episodes
D. Prolonged PT
Mild to severe bleeding episodes
56
Refer to the following results:
PT = prolonged
APTT = prolonged
PLT count = decreased
Which disorder may be indicated?
A. Factor VIII deficiency
B. von Willebrand disease
C. DIC
D. Factor IX deficiency
DIC
57
Which of the following is a predisposing condition for the development of DIC?
A. Adenocarcinoma
B. Idiopathic thrombocytopenic purpura (ITP)
C. Post transfusion purpura (PTP)
D. Heparin-induced thrombocytopenia (HIT)
Adenocarcinoma
58
Factor XII deficiency is associated with:
A. Bleeding episodes
B. Epistaxis
C. Decreased risk of thrombosis
D. Increased risk of thrombosis
Increased risk of thrombosis
59
The following results were obtained on a patient: normal PLT count and function, normal PT, and prolonged APTT. Which of the following disorders is most consistent
with these results?
A. Hemophilia A
B. Bernard–Soulier syndrome
C. von Willebrand disease
D. Glanzmann thrombasthenia
Hemophilia A
60
The following laboratory results were obtained from a 40-year-old woman: PT = 20 sec; APTT = 50 sec; TT = 18 sec. What is the most probable diagnosis?
A. Factor VII deficiency
B. Factor VIII deficiency
C. Factor X deficiency
D. Hypofibrinogenemia
Hypofibrinogenemia
61
When performing a factor VIII activity assay, a patient’s plasma is mixed with:
A. Normal patient plasma
B. Factor VIII–deficient plasma
C. Plasma with a high concentration of factor VIII
D. Normal control plasma
Factor VIII–deficient plasma
62
The most suitable product for treatment of factor VIII deficiency is:
A. Fresh frozen plasma (FFP)
B. Factor VIII concentrate
C. Prothrombin complex concentrate
D. Factor V Leiden
Factor VIII concentrate
63
Which of the following is associated with an abnormal PLT aggregation test result?
A. Factor VIII deficiency
B. Factor VIII inhibitor
C. Lupus anticoagulant
D. Afibrinogenemia
Afibrinogenemia
64
Refer to the following results:
PT = normal
APTT = prolonged
PLT count = normal
PLT aggregation to ristocetin = abnormal
Which of the following disorders may be indicated?
A. Factor VIII deficiency
B. DIC
C. von Willebrand disease
D. Factor IX deficiency
von Willebrand disease
65
Which results are associated with hemophilia A?
A. Prolonged APTT, normal PT
B. Prolonged PT and APTT
C. Prolonged PT, normal APTT
D. Normal PT and APTT
Prolonged APTT, normal PT
66
Fibrin monomers are increased in which of the following conditions?
A. Primary fibrinolysis
B. DIC
C. Factor VIII deficiency
D. Fibrinogen deficiency
DIC
67
Which of the following is associated with multiple factor deficiencies?
A. An inherited disorder of coagulation
B. Severe liver disease
C. Dysfibrinogenemia
D. Lupus anticoagulant
Severe liver disease
68
Normal PT and APTT results in a patient with poor wound healing may be associated with:
A. Factor VII deficiency
B. Factor VIII deficiency
C. Factor XII deficiency
D. Factor XIII deficiency
Factor XIII deficiency
69
Fletcher factor (prekallikrein) deficiency may be associated with:
A. Bleeding
B. Thrombosis
C. Thrombocytopenia
D. Thrombocytosis
Thrombosis
70
One of the complications associated with a severe hemophilia A is:
A. Hemarthrosis
B. Mucous membrane bleeding
C. Mild bleeding during surgery
D. Immune-mediated thrombocytopenia
Hemarthrosis
71
The most common subtype of classic von Willebrand disease is:
A. Type 1
B. Type 2A
C. Type 2B
D. Type 3
Type 1
72
Prolonged APTT and PT are corrected when mixed with normal plasma. Which factor is most likely deficient?
A. Factor VIII
B. Factor V
C. Factor XI
D. Factor IX
Factor V
73
Which characteristic describes antithrombin (AT)?
A. It is synthesized in megakaryocytes
B. It is activated by protein C
C. It is a cofactor of heparin
D. It is a pathological inhibitor of coagulation
It is a cofactor of heparin
74
Which laboratory test is affected by heparin therapy?
A. Thrombin time
B. Fibrinogen assay
C. Protein C assay
D. Protein S assay
Thrombin time
75
Abnormal APTT caused by a pathological circulating anticoagulant is:
A. Corrected with factor VIII–deficient plasma
B. Corrected with factor IX–deficient plasma
C. Corrected with normal plasma
D. Not corrected with normal plasma
Not corrected with normal plasma
76
The lupus anticoagulant affects which of the following tests?
A. Factor VIII assay
B. Factor IX assay
C. VWF assay
D. Phospholipid-dependent assays
Phospholipid-dependent assays
77
Which statement about warfarin (Coumadin) is accurate?
A. It is a vitamin B antagonist
B. It is not recommended for pregnant and lactating women
C. It needs AT as a cofactor
D. APTT test is used to monitor its dosage
It is not recommended for pregnant and lactating women
78
Which statement regarding protein C is correct?
A. It is a vitamin K–independent zymogen
B. It is activated by fibrinogen
C. It activates cofactors V and VIII
D. Its activity is enhanced by protein S
Its activity is enhanced by protein S
79
Which of the following is an appropriate screening test for the diagnosis of lupus anticoagulant?
A. Thrombin time
B. Diluted Russell viper venom test (DRVVT)
C. D-dimer test
D. Fibrinogen assay
Diluted Russell viper venom test (DRVVT)
80
Which of the following is most commonly associated with activated protein C resistance
(APCR)?
A. Bleeding
B. Thrombosis
C. Epistaxis
D. Menorrhagia
Thrombosis
81
A 50-year-old man has been on heparin for the past 7 days. Which combination of tests
is expected to be abnormal?
A. PT and APTT only
B. APTT, TT only
C. APTT, TT, fibrinogen assay
D. PT, APTT, TT
PT, APTT, TT
82
Which of the following drugs inhibits ADP-mediated PLT aggregation?
A. Heparin
B. Warfarin
C. Aspirin
D. Prasugrel
Prasugrel
83
Thrombin–TM complex is necessary for activation of:
A. Protein C
B. AT
C. Protein S
D. Factors V and VIII
Protein C
84
Which test is used to monitor heparin therapy?
A. INR
B. Chromogenic anti–factor Xa assay
C. TT
D. PT
Chromogenic anti–factor Xa assay
85
Which test is commonly used to monitor warfarin therapy?
A. INR
B. APTT
C. TT
D. Ecarin time
INR
86
Which clotting factors (cofactors) are inhibited by protein S?
A. Factors V and X
B. Factors Va and VIIIa
C. Factors VIII and IX
D. Factors VIII and X
Factors Va and VIIIa
87
Which drug promotes fibrinolysis?
A. Warfarin
B. Heparin
C. Urokinase
D. Aspirin
Urokinase
88
Diagnosis of lupus anticoagulant is confirmed by which of the following criteria?
A. Decreased APTT
B. Correction of APPT by mixing studies
C. Neutralization of the antibody by high concentration of phospholipids
D. Confirmation that abnormal coagulation tests are related to factor deficiencies
Neutralization of the antibody by high concentration of phospholipids
89
Which of the following abnormalities is consistent with the presence of lupus
anticoagulant?
A. Decreased APTT/bleeding complications
B. Prolonged APTT/thrombosis
C. Prolonged APTT/thrombocytosis
D. Thrombocytosis/thrombosis
Prolonged APTT/thrombosis
90
Which of the following is a characteristic of LMWH?
A. Generally requires monitoring
B. Specifically acts on factor Va
C. Has a longer half-life compared with unfractionated heparin (UFH)
D. Can be used as a fibrinolytic agent
Has a longer half-life compared with unfractionated heparin (UFH)
91
Which of the following tests is most likely to be abnormal in patients taking aspirin?
A. PLT morphology
B. PLT count
C. PLT aggregation
D. PT
PLT aggregation
92
Which of the following is associated with AT deficiency?
A. Thrombocytosis
B. Thrombosis
C. Thrombocytopenia
D. Bleeding
Thrombosis
93
Which of the following may be associated with thrombotic events?
A. Decreased protein C
B. Increased fibrinolysis
C. Afibrinogenemia
D. Idiopathic thrombocytopenic purpura
Decreased protein C
94
Aspirin resistance may be associated with:
A. Bleeding
B. Factor VIII deficiency
C. Thrombosis
D. Thrombocytosis
Thrombosis
95
Prolonged TT is indicative of which of the following antithrombotic agents?
A. Prasugrel
B. Clopidogrel
C. Aspirin
D. Heparin
Heparin
96
Screening tests for thrombophilia should be performed on:
A. All pregnant women because of the risk of thrombosis
B. Patients with a negative family history
C. Patients with thrombotic events occurring at a young age
D. Patients who are receiving anticoagulant therapy
Patients with thrombotic events occurring at a young age
97
Prothrombin G20210A is characterized by which of the following causes and
conditions?
A. Single mutation of prothrombin molecule/bleeding
B. Single mutation of prothrombin molecule/thrombosis
C. Decreased levels of prothrombin in plasma/thrombosis
D. Increased levels of prothrombin in plasma/bleeding
Single mutation of prothrombin molecule/thrombosis
98
Factor V Leiden promotes thrombosis by preventing:
A. Inactivation of factor Va
B. Activation of factor V
C. Activation of protein C
D. Activation of protein S
Inactivation of factor Va
99
What is the approximate incidence of antiphospholipid antibodies in the general
population?
A. Less than 1%
B. 1%–2%
C. 3%–8%
D. 10%–15%
1%–2%
100
Which of the following laboratory tests is helpful in the diagnosis of aspirin resistance?
A. APTT
B. PT
C. PLT count and morphology
D. PLT aggregation
PLT aggregation
101
Which of the following complications may occur as a result of decreased tissue factor
pathway inhibitor (TFPI)?
A. Increased episodes of hemorrhage
B. Increased risk of thrombosis
C. Impaired PLT plug formation
Increased risk of thrombosis
102
Factor VIII inhibitors occur in
__________
of patients with factor VIII deficiency.
A. 40%–50%
B. 30%–40%
C. 25%–30%
D. 20%–25%
20%–25%
103
Which therapy and resulting mode of action are appropriate for the treatment of a
patient with a high titer of factor VIII inhibitors?
A. Factor VIII concentrate to neutralize the antibodies
B. Recombinant factor VIIa (rVIIa) to activate factor X
C. Factor X concentrate to activate the common pathway
D. FFP to replace factor VIII
Recombinant factor VIIa (rVIIa) to activate factor X
104
The Bethesda assay is used for which determination?
A. Lupus anticoagulant titer
B. Factor VIII inhibitor titer
C. Factor V Leiden titer
D. Protein S deficiency
Factor VIII inhibitor titer
105
Hyperhomocysteinemia may be a risk factor for:
A. Bleeding
B. Thrombocythemia
C. Thrombosis
D. Thrombocytopenia
Thrombosis
106
Which drug may be associated with DVT?
A. Aspirin
B. tPA
C. Oral contraceptives
D. Clopidogrel (Plavix)
Hemostasis/Appl
Oral contraceptives
107
Argatroban may be used as an anticoagulant drug in patients with:
A. DVT
B. Hemorrhage
C. TTP
D. Thrombocytosis
DVT
108
Heparin-induced thrombocytopenia (HIT) results from:
A. Antibodies to heparin
B. Antibodies to PLTs
C. Antibodies to PF4
D. Antibodies to heparin–PF4 complex
Antibodies to heparin–PF4 complex
109
Which laboratory test is used to screen for APCR?
A. Mixing studies with normal plasma
B. Mixing studies with factor-deficient plasma
C. Modified APTT with and without APC
D. Modified PT with and without APC
Modified APTT with and without APC
110
Ecarin clotting time may be used to monitor:
A. Heparin therapy
B. Warfarin therapy
C. Fibrinolytic therapy
D. Bivalirudin
Bivalirudin
111
Which of the following may interfere with the APCR screening test?
A. Lupus anticoagulant
B. Protein C deficiency
C. AT deficiency
D. Protein S deficiency
Lupus anticoagulant
112
Thrombophilia may be associated with which of the following disorders?
A. Afibrinogenemia
B. Hypofibrinogenemia
C. Factor VIII inhibitor
D. Hyperfibrinogenemia
Hyperfibrinogenemia
113
Which of the following anticoagulant drugs can be used in patients with HIT?
A. Warfarin
B. Heparin
C. Aspirin
D. Argatroban
Argatroban
114
Which of the following is the preferred method to monitor heparin therapy at the point
of care during cardiac surgery?
A. APTT
B. ACT
C. PT
D. TT
ACT
115
Mrs. Smith has the following laboratory results and no history of bleeding:
APTT = prolonged
APTT results on a 1:1 mixture of the patient’s plasma with normal plasma:
Preincubation: prolonged APTT
2-hour incubation: prolonged APTT
These results are consistent with:
A. Factor VIII deficiency
B. Factor VIII inhibitor
C. Lupus anticoagulant
D. Protein C deficiency
Lupus anticoagulant
116
Which test may be used to monitor LMWH therapy?
A. APTT
B. INR
C. Anti–factor Xa heparin assay
D. ACT
Anti–factor Xa heparin assay
