Harrison's 238: Cardiomyopathy and myocarditis

Question 1

Cardiomyopathy is…

Answer 1

…disease of the heart muscle.

Question 2

What are the 3 traditional classifications of cardiomyopathy?

Answer 2

1) Dilated
2) Restrictive
3) Hypertrophic

Question 3

Define “dilated” cardiomyopathy

Answer 3

Enlarged left ventricle with decreased systolic function (decreased EF)

Question 4

What is myocarditis?

Answer 4

Inflammatory process attributed to organisms that can invade myocardium, produce cardiotoxins, and trigger chronic inflammatory response

Question 5

What is Chagas’ disease? Where is it commonly found?

Answer 5

#Third most common parasitic infection in the world, and the most common cause of cardiomyopathy
# Common to Central & South America

Question 6

What is peri-partum cardiomyopathy?

Answer 6

Cardiomyopathy developing during the last trimester or within 6 months post-partum, in the absence of preexisting cardiac disorder.

Question 7

What’s the most common cause of toxic cardiomyopathy?

Answer 7

Alcohol

Question 8

How much alcohol is necessary to cause toxic cardiomyopathy?

Answer 8

Estimated to be about 6 drinks per day for 5-10 years

Question 9

Most common drug type implicated in cardiomyopathy?

Answer 9

Chemotherapy

Question 10

Which is the least common type of cardiomyopathy?

Answer 10

Restrictive

Question 11

What are some causes of restrictive cardiomyopathy?

Answer 11

Amyloidosis
Inherited metabolic defect
Hemochromatosis
Radiation
Scleroderma
Radiation
Drugs

Question 12

What is hypertrophic cardiomyopathy?

Answer 12

Cardiomyopathy characterized by marked left ventricular hypertrophy in the absence of other causes.

Question 13

What does hypertrophic cardiomyopathy look like upon presentation?

Answer 13

#Btwn the ages of 20-40
#Dyspnea on exertion
#Chest pain (either typical or atypical)
#Palpitations