HCV

Question 1

Structure

Answer 1

• Serum hepatitis
• ss + RNA
• enveloped
• icosohedral capsid
• NANB (non A non B)

Question 2

Pathogenesis

Answer 2

• 30% of world infected
• Std
• placental
• blood transmission
• very mutant (changes AG structure a lot)

Question 3

Disease ( IP, infection)

Answer 3

1) IP: 5-10weeks
2) similar to HBV
3) sub clinical infections
4) 85%chrinic infections ( look at ALT levels in blood- wavy curve)
5) high rush for cirrohsis or hepatocellular carcinoma, if chronic active hepatitis

Question 4

Diagnostics

Answer 4

Many develop chronic active hepatitis

Question 5

Treatment/ immunity

Answer 5

1) Unspecified prevention
2) anti- HCV after months

Treatment
1) with interferon alpha results in resolution of liver inflammation in 50% of cases

Question 6

Virus

Answer 6

flaviviridae (hcv)