HCV drugs

Question 1

protease inhibitors end in ___

Answer 1

previr

Question 2

replication complex inhibitors end in

Answer 2

asvir

Question 3

polymerase inhibitors end in

Answer 3

buvir

Question 4

what are the protease inhibitors

Answer 4

glecaprevir, voxilaprevir, grazoprevir

Question 5

what are the replication inhibitors

Answer 5

velpatasvir, ledipasvir, pibrentasvir, elbasvir

Question 6

what is the polymerase inhibitor

Answer 6

sofosbuvir

Question 7

what is sovaldi

Answer 7

sofosbuvir

Question 8

what is harvoni

Answer 8

ledipasvir/sofosbuvir

Question 9

what is epclusa

Answer 9

sofosbuvir/velpatasvir

Question 10

what is vosevi

Answer 10

sofosbuvir/velpatasvir/voxilaprevir

Question 11

what is mavyret

Answer 11

glecaprevir/pibrentasvir

Question 12

what is zepatier

Answer 12

elbasvir/grazoprevir

Question 13

ribavirin side effect

Answer 13

hemolytic anemia (BW)

Question 14

ribavirin counseling

Answer 14

pregnancy category x: counsel both males and females to avoid pregnancy during treatment and for 6 months after

Question 15

sofosbuvir contraindication/drug interaction

Answer 15

amiodarone: severe bradycardia

Question 16

recommended treatments for treatment naive WITHOUT cirrhosis

Answer 16

mavyret x 8 weeks, epclusa x 12 weeks

Question 17

recommended treatments for treatment naive WITH cirrhosis (compensated, child pugh class A)

Answer 17

mavyret x 8 weeks for genotype 1-6. epclusa x 12 weeks for all genotypes except 3

Question 18

first line for treatment failure if sofosbuvir based?

Answer 18

vosevi x 12 weeks (+ ribavirin if genotype 3)

Question 19

first line for treatment failure if mavyret?

Answer 19

mavyret PLUS ribavirin x 16 weeks

Question 20

alternate treatment for sofosbuvir based failure

Answer 20

mavyret x 16 weeks

Question 21

alternate treatment for mavyret failure

Answer 21

vosevi x 12 weeks (+ ribavirin if compensated)

Question 22

describe the drug interaction with acid lowering therapy

Answer 22

velpatasvir and ledipasvir solubility requires acidic pH, acid lowering therapy reduces concentrations

Question 23

which medications should you be careful with antacids

Answer 23

harvoni, epclusa, vosevi

Question 24

counseling for antacid

Answer 24

separate by 4 hr

Question 25

counseling for H2RA

Answer 25

simultaneous or sep by 12 hr

Question 26

counseling for PPI

Answer 26

max omeprazole 20 mg QD, take simultaneously for harvoni and vosevi. For epclusa, only if necessary and take it 4 hours before PPI.

Question 27

describe the drug interactions with cholesterol lowering agents

Answer 27

DAA inhibit OATP and P-gp which inhibits statin metabolism. increases AUC, myalgia, and rhabdomyolysis risk

Question 28

which drugs should you avoid certain statins for

Answer 28

mavyret, harvoni, and vosevi

Question 29

what is the drug interaction with anticonvulsants/inducers

Answer 29

strong CYP3A4 and P-gp inducers decrease DCC AUC

Question 30

which anticonvulsants and inducers should you stop

Answer 30

carbamazepine, oxcarbazepine, phenobarbital, phenytoin, primidone, st johns wort

Question 31

which antimicrobials should you avoid

Answer 31

rifampin, rifabutin

Question 32

what is the interaction with immunosuppressants

Answer 32

cyclosporine is OATP inhibitor, leads to AUC increase grazoprevir and voxilaprevir

Question 33

which drugs do you take with food

Answer 33

mavyret and vosevi, ribavirin

Question 34

which drugs are not pangeotypic

Answer 34

harvoni, zepatier

Question 35

____ is contraindicated with rifampin

Answer 35

vosevi

Question 36

the drug that is never monotherapy

Answer 36

ribavirin

Question 37

adverse effects of most DAAs

Answer 37

fatigue, headache, nausea

Question 38

what are the treatment recommendations for kids over 3

Answer 38

mavyret x 8 weeks with food, harvoni x 12 weeks, epclusa x 12 weeks

Question 39

foods you can recommend the kiddos to take with mavyret

Answer 39

peanut butter, cream cheese, hazelnut spread, greek yogurt

Question 40

what foods can kids take with epclusa and harvoni

Answer 40

nonacidic soft foods, chocolate syrup, ice cream

Question 41

which therapies for kids are all genotypes

Answer 41

mavyret and epclusa

Question 42

harvoni for kids: what genotypes

Answer 42

all but 2 and 3

Question 43

if mixing with food, must take within __ minutes of mixing

Answer 43

15

Question 44

which statin is the safest

Answer 44

pravastatin

Question 45

which drug has renal dose adjustments

Answer 45

ribavirin

Question 46

which drugs increase LFT with ethinyl estradiol

Answer 46

mavyret, vosevi

Question 47

____ is contraindicated in Child Pugh Class C

Answer 47

mavyret

Question 48

_____is contraindicated in child pugh class B or C

Answer 48

zepatier

Question 49

which genotypes does zepatier cover

Answer 49

1a, 1b, 4

Question 50

which statins do you avoid for mavyret

Answer 50

atorvastatin, lovastatin, simvastatin

Question 51

which statins do you avoid for harvoni

Answer 51

rosuvastatin

Question 52

which statins do you avoid for vosevi

Answer 52

fluvastatin, lovastatin, pitavastatin, rosuvastatin, simvastatin