HD

Question 1

C5a

Answer 1

chemoattractant for neutrophils, eosinophils, basophils, monocytes

Question 2

C3a, C4a, C5a

Answer 2

anaphylatoxins, trigger granule release (vascular changes)

Question 3

CD59

Answer 3

Prevents assembly of MAC

Question 4

Hereditary Angioneurotic Edema

Answer 4

C1 inhibitor deficiency

Question 5

Paroxysmal Nocturnal Hemoglobinurea

Answer 5

CD59 failure (cannot inhibit MAC)

Question 6

70-80% of Ig in body

Answer 6

IgA

Question 7

Cytokines that induce isotope switch to IgA

Answer 7

TGF-beta and IL-5

Question 8

Gut-homing receptors

Answer 8

a4b7 and CCR9

Question 9

Secretion of IgA

Answer 9

Via pIgR (becomes secretory component)

Question 10

Type I hypersensitivity

Answer 10

Immediate, primed allergy cells with IgE degranulate

Question 11

Type II hypersensitivity

Answer 11

Antibody-mediated, Abs attach to patient’s own cells, also called cytotoxic

Question 12

Type III hypersensitivity

Answer 12

Immune complex deposition in tissues

Question 13

Type IV hypersensitivity

Answer 13

T cell-mediated, self-peptides haptenated to contact-sensitizing agent, APC primes a T cell and activates macrophages

Question 14

Valency

Answer 14

How many identical epitopes on an antigen

Question 15

Avidity

Answer 15

Overall attachment strength of Ab to antigen

Question 16

Arthus reaction

Answer 16

Sensitized individual’s IgG forms immune complexes with antigen, bind Fc receptors, inflammation and classical complement pathway

Question 17

Serum sickness

Answer 17

Large and continuous dose of antigen, start making IgG around day 6–immune complexes form and deposit in blood vessel walls

Question 18

MC-T vs. MC-TC

Answer 18

MC-T: tryptase, mucosa (resp. and GI)

MC-TC: tryptase and chymase, connective tissue (dermis, submucosa)