Headache and Migraine Flashcards
(36 cards)
What are the classifications of the types of headaches?
Primary: Tension Type Headache, Migraine, Trigeminal Autonomic cephalagias (TACs), Other primary HA disorders
Secondary: Trauma or injury to head and/or neck, cranial or cervical vascular disorder, non-vascular intracranial disorder, infections, homeostasis disorder, psychiatric disorder, HA/facial pain attributed to disorder of cranium, neck, eyes, ears, nose, sinuses, teeth, mouth or other facial/cervical structures
What are the impt triage criteria?
SNNOOP10
Systemic symptoms incl fever
Neoplasm in Hx
Neurologic defecit of dysfn
Onset of headache sudden or abrupt
Older age (>50y.o.)
Pattern change or recent onset of headache
Positional headache
Precipitated by sneezing, coughing, exercise
Papilledema
Progressive headache w atypical presentation
Pregnancy or puerperium = 6 weeks post childbirth
Painful eye w autonomic features
Post traumatic onset of headache
Pathology of immune sys as HIV/immunocompromised
Painkiller overuse or new drug at onset of headache
What is SNNOOP10 for?
To rule out secondary headache or escalate for medical attention when it satisfies criteria for secondary criteria
Describe the pathophysiology of headache and migraine.
Pain sensing nerves of the muscles and blood vessels that surround the head face and neck are set off by stress, muscle tension, enlarged blood vessels etc.
Nerves sense messages to brain –> pain
Myofascial mechanisms esp cervical muscles involves, vascular mechanisms involved in peripheral sensitisation
Central mechanisms involved in central sensitisation, dysfn in descending pain modulation
Genetic disposition plays a role in pathophysiology
Vasodilation of intrcranial extracerebral blood vessels results in activation of perivascular trigeminal nerves
The activation of TGN releases vasoactive neuropeptides to promote neurogenic inflamm
Central pain transmission may activate other brainstem nuclei, resulting in assoc symptoms (NV, photophobia, phonophobia)
Agonists of vascular and neuronal 5HT1 rece subtypes known to result in vasoconstriction of meningreal blood vessels and inhib vasoactive peptide release & pain signal transmission (reversal of migraine)
What are the risk factors for TTH?
Fam Hx of polymorphism
Female
Depression and anxiety
Insomnia
Temporomandibular joint disorder
Vit B12, D def
Physical/emotional stress
Activities that cause the head to be held in one position for a long time
Alc
Caffeine
Cold/flu or sinus infections
Dehydration
Hunger
Describe the epidemiology of TTH.
Most common type of primary headache - est 1y prevalence 38-86%
Peaks in 4th decade
Female>Male
Infrequent episodic TTH 64%
Frequent episodic TTH 22%
Chronic TTH 0.9-2.2%
What are the specific classification criteria for episodic TTH?
Infrequent ETTH
Freq: min 10 headache episodes, average <1d/month (<12 d/year)
Duration: 30min-7d
Frequent ETTH
Freq: min 10 headache episodes, ave 1-14d/month for >3mo BUT <180days/year
Duration: 30min-7d
What are the specific classification criteria for CTTH?
Freq: >= 15d/month on ave for >3mo (>=180d/year)
Duration: h-d, unremitting
What are the shared classification criteria for ETTH and CTTH?
At least two of the four following:
- Bilateral
- Pressing or tightening (non-pulsating) quality
- Mild or moderate intensity
- Not aggravated by routine physical activity at walking or climbing stairs
Both of the following:
For ETTH
1. No N/V
2. No more than one of photophobia or phonophobia
For CTTH
1. No more than one or photophobia, phonophobia or mild nausea
2. Neither moderate or severe nausea nor vomiting
Not better accounted by another ICHD-3 diagnosis
What are the principles for TTH management?
Acute TTH:
Pharmacological
- Paracetamol (along or w caffeine), aspirin
- NSAIDs: Ibuprofen, Diclofenac, Ketoprofen
Chronic TTH:
Pharmacological Prophylaxis
- TCA e.g. amitriptyline
- Mirtazapine, Venlafaxine
Non-pharmacological
- Cognitive behaviour therapy (CBT), biofeedback relaxation
- PT and/or OT
- Lifestyle modif (incl sleep hygiene)
What are the goals of management for TTH?
Pain relief, prevent progression to chronic TTH
What are the signs and symptoms of TTH?
Pain location: Bilateral
Pain quality: Tightening, pressing, band-like, constant
Pain intensity: Mild to moderate intensity
Effect on activities: Not aggravated by routine activities of daily living
Onset:
Time: 30min-7d, may be better in morning, worse in evening
Others:
- Pericranial or cervical muscle tenderness
- Stiffness in neck
- Decreased appetite
Describe the pathophysiology of migriane.
Vasodilation of intrcranial extracerebral blood vessels results in activation of perivascular trigeminal nerves
The activation of TGN releases vasoactive neuropeptides to promote neurogenic inflamm
- CGRP, PACAP
- Released in mayy anatomical regions, incl trigeminal vasculature and cranial parasympathetic sys
Central pain transmission may activate other brainstem nuclei, resulting in assoc symptoms (NV, photophobia, phonophobia)
Agonists of vascular and neuronal 5HT1 rece subtypes are known to result in vasoconstriction of meningeal blood vessels and inhibition of vasoactive neuropeptide release and pain signal transmission (reversal of migraine)
What is the pathophysiology of migraine wrt migraine phases?
- Prodrome phase
- Hypothalamus and neuropeptide release implicated
- Hypothalamus is the target for hypothalamic peptides and modulators - Aura
- Cotex triggers pain centres –> central sensitisation via cortical spreading depolarisation (large wave of slow spreading depolarisation within grey matter)
- Cortex also involved w cognitive symptoms - Headache
- Sensitisation of central and peripheral trigeminal vascular sys
- Release of neuropeptides - Postdrome
- Cervical vessels, midbrain & hypothalamus implicated
What are the signs and symptoms of migraine?
Pain location: Unilateral or bilateral
Pain quality: Throbbing, pulsating
Pain intensity: Moderate to severe
Effect on activities: Aggravated by or causes avoidance of routine activities of daily living
Time: 4-72h
Other: NV, photophobia, phonophobia, aura (visual[“light show”], sensory, speech disturbance)
Describe the epidemiology of migraine.
2nd most burdensome disease worldwide in terms of years lived w disability
Lifetime prevalence of migraine in SG = 9.3%
7.7% of ppl w migraine hv chronic migraine
What are the signs & symptoms of migraine wrt the migraine phases?
- Prodrome
- Fatugue
- Food cravings
- Nausea
- Cognitive symptoms
- Neck discomfort
- Photo, phono, osmophobia - Aura
- xp by 20-30% of pts w migraine
- Visual aura = “light display”
- Sensory disturbance
- Speech disturbance
- Motor symptoms - Headache (Ictal)
- Mod-severe head pain
- NV
- Photo,phonophobia
- Allodynia - scalp sensitivity, no cap, ponytail, glasses on nose bridge
- Cranial autonomic symptoms
- Cognitive symptoms - Prodrome
- NV
- Photo, phonophobia
- Fatigue
- Cognitive symptoms
- Neck discomfort - Interictal
- Cont to xp migraine symptoms in absence of headache
- Cognitive symptoms
- Fatigue
What are the 5 phases of migraine?
- Prodrome (h-d before)
- Aura (5-60min)
- Headache [Ictal] (4-72h)
- Postdrome (<=12-24h)
- Interictal
What are the ways we classify migraines?
W vs without aura
Episodic vs chronic
What is the criteria to classify migraine without aura?
At least 5 attacks fulfilling below
- Headache lasting 4-72h (when untreated or unsuccessfully treated)
- Headache has at least two of the following charac:
a. Unilateral
b. Pulsating quality
c. Mod-severe intensity
d. Aggravation by or causing avoidance of routine physical activity (e.g. walking or climbing stairs)
- During headache at least one of the following
1. N and/or V
2. Photo AND phonophobia
Not better accounted for by another ICHD-3 diagnosis
What is the criteria to classify migraine with aura?
At least 2 attacks fulfilling below
- At least one of the following fully reversible aura:
a. Visual
b. Sensory
c. Speech and/or lang
d. Motor
e. Brainstem
f. Retinal
- At least three of the following six:
1. Min 1 aura symptom that speads gradually over >=5min
2. 2 or more aura symptoms occur in succession
3. Each indi aura symptom lasts 5-60min
4. At least 1 aura symptom is unilateral
5. At least 1 aura symptom is positive
6. The aura is accompanied or followed within 60min by headache
Not better acc by another ICHD-3 diagnosis
What is the classification criteria for epidsodic migraine?
In lifetime, >=5 migraine attacks lasting 4-72h
What is the classification criteria for chronic migraine?
Over >3mo
1. >=15MHD = a day w migraine type OR TTH
AND
2. >=8MMD
- >=2 migriane characteristics (symptoms)
- If no aura, >=1 of the following migraine symptoms
a. Photo/phonophobia
b. N/V
What are the non-pharmacological management strategies for migraine?
Neuromodulation
- FDA approved 4 devices that make use of feedback mech to tries to interface pain transmission process and stop it
Behavioural cognitive therapy
Biofeedback
Relaxation therapies
