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Flashcards in heart defect associations Deck (16):
1

heart defect associated with 22q11 syndromes

truncus arteriosus, tetralogy of fallot

2

down syndrome heart defects

ASD, VSD, AV septal defect (endocardial cushion defect)

3

congenital rubella and the heart

septal defects, PDA, pulm artery stenosis

4

turner syndrome and the heart

bicuspid aortic valve and preductal coarctation of the aorta

5

marfan syndrome and the heart

MVP (mitral valve prolapse), thoracic aortic aneyrusm, and aortic regurg

6

infant of a diabetic mother

transposition of the great vessels

7

acute bacterial endocarditis

due to high virulence organism, like S. aureus. can attack normal valves. large vegitations. In IV drug users, it is likely to attack the tricuspid valve

8

subacute bacterial endocarditis

due to a lower virulence organism, like viridans strep. smaller vegetations on congenitally abnormal or diseased valves. gradual onset

9

culture negative bacterial endocarditis

most likely coxiella or bartonella (or in pathoma, HACEK organisms: hemophius, acinobacillus, cardiobacterium)

10

What bugs are especially likely to cause tricuspid endocarditis in IV drug users?

S. aureus, pseudomonas, C. albicans.

11

complications of bacterial endocarditis

chordae rupture, glomerulonephritis, suppurative pericarditis, emboli

12

rheumatic heart disease characteristics

evidence of prior GAS infection, as seen with an ASO titer or an anti-DNase B titer
minor criteria, like fever and elevated ESR, and major criteria: JONES: migratory polyarthritis, heart problems, subcutaneous nodules, erythema marginatum, sydenham chorea.

13

How doe people die early with rhemuatic fever?

myocarditis

14

What are sequelae of rheumatic heart disease?

valvular disease: mitral > aortic >> tricuspid. the early lesion is likely to be mitral valve regurgitation; later lesions are due to scarring and cause mitral valve stenosis.

15

Pathologic findings of rheumatic heart disease

aschoff bodies (granuloma with giant cells) and anitschkow cells (enlarged macrophages with ovoid, wavy, rod-like nuclei.

16

What kind of immune reaction is rheumatic heart disease? What is the antigen?

type II hypersensitivity. antibodies to M protein that cross react with self antigens