Heart failure Flashcards

1
Q

How is diastolic HF treated?

A

diuretics, vasodilators, inotropic drugs, BB, hydralazine/nitrates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What care the common signs of HF?

A

systolic: cough, diastolic: jugular distention

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which stages of HF are at risk for HF?

A

A and B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which stages of HF are in HF?

A

C and D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

If in systolic HF, what is the first choice of drug therapy?

A

diuretic + ACEi, add BB if needed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

If in systolic HF and ACEi + diuretic + BB isnt working, what should you add?

A

aldosterone antagonist or switch to ARB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

If in systolic HF and diuretic + ACEi + BB + aldosterone antagonist arent working how should you treat?

A

digoxin, LVAD, transplant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

define stage A HF

A

at risk for developing HF without structural heart disease or sxs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are pts like with stage A HF?

A

HTN, atherosclerosis, diabetes, obesity, metabolic syndrome OR using cardiotoxins, FH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Define stage B HF

A

structural heart disease without sxs of heart failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are pts like with stage B HF?

A

previous MI, LV hypertrophy and low LVEF, asymptomatic valvular disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Define stage C HF

A

structural heart disease with prior or current sxs of HF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are patients like with stage C HF?

A

SOB, fatigue, reduced exercise tolerance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Define stage D HF

A

refractory HF requiring specialized interventions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are pts like with stage D HF?

A

sxs at rest on maximum therapy, recurrent hospitalizations, require transplant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the proper order for staging HF?

A

A, B, C, I, II, III, IV, D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Describe stages I-IV of HF

A

I does well, II some DOE, III more DOE, IV SOB all the time

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

How is stage A HF treated?

A

Lifestyle mods (smoking cessation, no alcohol, exercise, fix lipids), Drugs: ACEi (diuretics only if obvious case of fluid problem)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

How is stage B HF treated?

A

Lifestyle mods, ACEi + BB in appropriate pts, diuretics only if obvious fluid problem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

How is stage C HF treated?

A

ACEi + BB + diuretic if needed, salt reduction, if refractory then digoxin or hydralazine/nitrates, aldosterone antagonists - biventricular pacing or defibrillators

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

How is stage D HF treated?

A

everything from A, B and C, end-of-life care, hospice, transplant, chronic ionotropes, permanent mechanical support

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What are cautions when prescribing diuretics in HF?

A

doesn’t stop disease progression, don’t use alone, can overcorrect, can become resistant, thiazides don’t work

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

How is furosemide prescribed if pts are refractory?

A

continuous infusion, IV for pts in hospital (don’t forget to 1/2 the dose)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What type of HF benefits most from ACEi?

A

severe HF - may improve sxs in days or weeks

25
What is the dose for captopril and enalapril in HF?
Captopril: 50mg tid, Enalapril: 10-20mg bid
26
what are the benefits of using BB in HF?
decreases post-MI mortality, reverse cardiac remodeling
27
What are the only 3 BB that can treat HF?
metoprolol, bisprolol, carvedilol
28
What shold LVEF be above
40
29
What labs should be checked on pts taking aldosterone antagonists?
electrolytes and creatinine within 1 week of start then monthly/bimonthly until K levels are stable
30
In what race do vasodilators work well in?
african americans
31
who should take vasodilators in HF?
low CO, volume overload, renal impairment (can't take ACEi or ARB)
32
What is BiDil?
hydralazine/isosorbide dinitrate, both these drugs don't work when administered together (seperately)
33
how do cardiac glycosides work?
act on ATPase to increase ATP
34
What is the effect of cardiac glycosides?
increased force of contraction and decreased rate of contraction
35
What is the halflife of cardiac glycosides?
36 hours, take approximately 2 weeks for steady state to estbalish
36
why is it easy to d/c cardiac glycosides?
levels deplete over a long period of time
37
true or false: serum levels do not correlate with clinical efficacy for cardiac glycosides
TRUE
38
true or false: cardiac glycosides have a narrow therapeutic index
TRUE
39
How can you CYA with cardiac glycosides?
get serum digitalis levels, above 1 can show signs of toxicity - don't stop, just leave it
40
who make good candidates for digoxin?
LVEF \<40%, NYHA class II, III, and IV sxs despite optimal therapy
41
what is an ADR for digoxin?
bradycardia (tachycardia if toxic, HR\>120)
42
what drugs increase digoxin levels?
antacids, Reglan, st. john's wort
43
what drugs decrease digoxin levels?
amiodarone, xanax, verapamil, spironolactone
44
How do you decrease the lowest digoxin dose and who should do this?
take it pod, those \>70y/o and who have bad kidneys
45
what is the MOA of dobutamine?
stimulate beta1 receptors of the heart
46
What are the effects of dobutamine?
chronotropic, hypertensive, arrhythmogenic, vasodilative effects
47
ADR for dobutamine?
tachycardia, HTN, ventricular activity, HOTN, PVC
48
How do BB interact with dobutamine?
BB antagonize effects of dobutamine resulting in unapposed increased vascular resistance
49
Who should receive dobutamine?
those waiting for transplant - doesn't prolong life
50
What are the inotropes you need to know?
dobutamine and milrinone
51
effects of milrinone
positive ionotropic and vasodilatory effect
52
what is BNP
b-type natriuretic peptide
53
MOA of BNP?
increases cGMP resulting in SM relaxation and vasodilation
54
what is the effect of BNP?
reduced pulmonary capillary wedge pressure and systemic arterial pressure
55
ADR of BNP?
HOTN
56
Dosing of BNP?
bolus and then infusion up to 96 hours
57
Class drug for BNP?
nesiritide
58
Why is BNP not used?
expensive, doesn't decrease mortality, causes renal problems