Heart Failure Flashcards

1
Q

What are the 3 most common causes of HF?

A
  • CAD - ischemic heart disease
  • Idiopathic, dilated cardiomyopathy
  • Valvular heart disease
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2
Q

What are 4 causes of restriction/obstruction to ventricular filling which can lead to HF?

A
  • RV infarct
  • Constrictive pericarditis
  • Mitral stenosis
  • Atrial myxoma
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3
Q

Using the AHA/ACC heart failure staging guidelines, what does stage A represent?

A

Pts at high risk for HF but WITHOUT structural heart disease or sx’s of HF

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4
Q

Using the AHA/ACC heart failure staging guidelines, what does stage B represent?

A

Asymptomatic pts WITH structural heart disease (i.e., LVH and/or impaired LV function (low EF), valvular dz, but hemodynamically stable

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5
Q

Using the AHA/ACC heart failure staging guidelines, what does stage C represent?

A

Pts WITH current or prior sx’s of HF WITH structural heart disease; SOB, fatigure, reduced exercise tolerance

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6
Q

Using the AHA/ACC heart failure staging guidelines, what does stage D represent?

A

Pts w/ refractory HF requiring specialized treatment/interventions

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7
Q

Using the NYHA functional classification for HF, what does class I-class IV represent?

A
  • Class I = asymptomatic; no physical activity limitations
  • Class II = no sx’s at rest; exertional sx’s w/ ordinary activity
  • Class III = no sx’s at rest; sx’s with minimal activity
  • Class IV = sx’s AT rest
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8
Q

Which imaging modality is essential in the evaluation of heart disease and for distinguishing systolic HF from diastolic HF?

A

Echocardiogram

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9
Q

List 5 causes of acute HF

A
  • Acute MI
  • Ruptured papillary muscle
  • MR
  • AI
  • Toxins
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10
Q

What are some distinguishing sx’s of systolic HF vs. diastolic HF?

A
  • Systolic HF = DOE, orthopnea, paroxysmal nocturnal dyspnea
  • Diastolic HF = SOB, DOE, and pulmonary edema
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11
Q

Which type of HF (diastolic/systolic) is associated with HTN, obesity, DM, CAD, and aging?

A

Diastolic HF

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12
Q

What are 3 common underlying causes of imparired ventricular relaxation leading to diastolic HF?

A
  • Acute ischemia
  • Myocardial fibrosis
  • Amyloidosis
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13
Q

List 6 causes of high-output HF?

A
  • Hyperthyroidisim
  • Anemia
  • Pregnancy
  • A-V fistula
  • Beriberi
  • Paget’s
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14
Q

What are the CO and EF like in high output HF?

A
  • High CO
  • Low EF
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15
Q

Which hormones released as a compensatory mechanism for HF causes an increased preload and which causes inceased afterload?

A
  • Aldosterone —> Na and H2O retention = ↑ preload, congestive sx’s and volume expansion
  • Angiotensin II –> vasoconstrictor –> ↑PVR (↑ afterload)
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16
Q

What is the effect of increased ADH released during compensatory phase of HF?

A
  • Stimulates thirst –> ↑ TBW and hyponatremia (dilutional)
  • preload (Na and H2O retention)
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17
Q

What are 2 major non-compliance issues which precipitate HF?

A
  • Non-compliance with diet = too much Na+, too many kcals, too many stimulants
  • Non-complance with meds = AE’s and cost
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18
Q

What are 4 medication classes which can worsen/precipitate HF?

A
  • Antiarrhythmics
  • Beta-blockers
  • CCBs
  • NSAIDs
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19
Q

How can anemia precipitate HF?

A

↑ O2 needs of tissues –> ↑ CO

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20
Q

By which mechanism do tachyarrhythmias lead to ischemia?

A

↓ diastolic filling time

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21
Q

What is the most common sx of HF?

A

Dyspnea –> ↓ arterial perfusion to organs and venous congestion

22
Q

Presence of which sx ↑ the likelihood of HF by 2-fold?

A

Paroxysmal nocturnal dyspnea

23
Q

Which PE of the lung is common with HF?

A

Crackles in lung due to pulmonary edema; may wheeze or cough (frothy- pink fluid)

24
Q

What are 4 signs/sx’s of RV failure?

A
  • Peripheral/sacral edema
  • Hepatomegalia
  • Ascites
  • ↑ JVD, hepatojugular reflex
25
When measuring JVP, how many cm's is considered **above normal**?
- **\>3 cm** above the **sternal angle** - **8-9 cm** in **total** distance above the **RA**
26
What are findings on a CXR associated with HF?
- **Cardiomgalia** - **Pulmonary edema** w/ **central peripheral** infiltrates - **↑ size** of vessels in **upper** portions of lungs - **Pleural effusions**
27
What is the usefulness of ordering a CBC, CMP, and UA when assessing possible HF?
- **CBC** looking for **anemia** 2' to chronic disease - **CMP** looking for **electrolyte imbalance**; pre-renal azotemia (BUN:Cr) - **UA** looking for **protein** in urine
28
Which lab must **always** be ordered in pt with HF who is \>65 yo with Afib?
**Thyroid**
29
What is the significance of a BNP \<100 pg/mL in terms of HF?
97% chance of **NO** HF
30
BNP is a neurohormone made in the ventricle that is sensitive to what (i.e., what are the stimuli)?
- **Sensitive** to ventricle stretching and volume overload. - **Preload/afterload** are the stimuli
31
What are pulmonary and liver problems which may mimic HF?
- **Pulmonary** = PE, asthma, and pneumonia - **Liver** = cirrhosis --\> ascites + edema
32
What is a non-pharmacologic approach to tx of HF if pt's Na+ is \<126 mEq/L?
**Fluid restriction** to **\<2 L/day**
33
Which type of activity should be avoided in HF and what should be encouraged?
- **AVOID** isometric acivity which ↑ SVR and afterload - **ENCOURAGE** isotonic activity - walking, hiking, golf
34
Why is enoxaparin (subcut lovenox) given to someone with HF?
**Prophylaxis** for **DVT's**
35
What does a class II recommendation mean in evidence based medicine?
**Conflicting** evidence and/or **divergence** of **opinion**
36
What does a grade of A-C represent in levels of evidence for evidence based recommendations?
- **A** = data from meta-analysis or **multiple** RCT's; **multiple** populations evaluated - **B** = data from **single** RCT or non-randomized studies; **limited** population evaluated - **C** = only consensus opinion of experts, case studies, or standard of care, **very limited** populations evaluated
38
Which drug class is useful for all NYHA functional classification with systolic HF?
ACE inhibitors
39
ACE-I should be used cautiously in pt's with what 2 underlying conditions?
- Renal insufficiency - K+ \>5 mEq/L
40
You should not give an ARB to a pt that had what AE from an ACE-I?
Angioedema
41
There is a survival benefit with using beta-blockers with what 2 underlying heart conditions?
- **Chronic** systolic HF - **Dilated cardiomyopathy**
42
Which NYHA functional classes of HF are beta-blockers recommended in?
**Class II** and **III**
43
The US Carvedilol HF program showed improvement in what 2 pt parameters?
- **Improved** LVEF - **Improved** well being
44
Beta-blockers should never be used in pt's who are in what classification of HF?
**Unstable** (Class **IV**)
47
Which level of evidence exists for the use of beta-blockers in all stable pt's with sx's of HF and reduced EF, unless contraindicated?
Level **A**
48
Diuretics are able to relieve congestive (pulmonary) sx's by decreasing what?
Preload
49
Which inotropic agent is useful in HFrEF and A.fib for ventricular rate control?
Digitalis
50
Which level of evidence exists for the use of Spironolactone in decreasing mortaility and decreasing HF hospitalization?
Level **B**
51
Which drug used in HF is an **inotropic vasodilator**?
**Milrinone** = PDE inhibitor
52
Which inotropic agent used in HF stimulates beta-1 receptors and is useful **short-term**?
Dopamine
53
Which drug given for HF is an **arterial** vasodilator, which reduced afterload and SVR?
Hydralazine
54
When is hydralazine plus isosorbide dinitrate used for HF?
- **Better** response in **African Americans** - Can be used in general if **intolerant** to ACE-I/ARB