Hem Onc 2

Question 1

Methotrexate applications

Answer 1

Breat cancer
Osteosarcoma
Lymphoma
Choriocarcinoma

Question 2

Methotrexate side effects

Answer 2

Mylosuppression
Muscotis
Renal tox

Question 3

Pemetrxed applications

Answer 3

Lung cancer

Question 4

Pemetrexed side effects

Answer 4

Mylosuppression (bad)
Mucositus
Skin rash

Question 5

Florouracil applications

Answer 5

Brest cancer
Colo rectal
Head and neck

Question 6

ATRA treats:

Answer 6

DIC in acute promylocytic leukemia

Question 7

Pre B cell disease and locations

Answer 7

Marrow

Acute leukoblastic leukemia/ lymphoma

Question 8

Mature naive B cell disease

Answer 8

Cll

Mantle cell lymphoma

Question 9

Germinal cell B cell diseases

Answer 9

Diffuse large B cell lymphoma
Focal lymphoma
Burkits
Hodgkins

Question 10

Plasma cell disease

Answer 10

Multiple myeloma

Question 11

Memory cell disease

Answer 11

Marginal cell lymphoma

Chronic LL

Question 12

CD34

Answer 12

Expressed only on stem cells

Not on mature cells

Question 13

Brentuximab

Answer 13

CD30 target
3rd line lymphoma treatment

Chemo smart bomb

Question 14

Rituximab

Answer 14

Targets CD 20

B cell lymphoma

Question 15

BCL 2

Answer 15

Anti apoptosis gene

mutated with t(14:18)
Mutated in follicular lymphoma

Question 16

cd 20

Answer 16

On the surface of mature B cells

Not on the surface of b stem cells or plasma cells

Question 17

CD56

Answer 17

Multiple myeloma marker

Question 18

CD 38 and CD 138

Answer 18

Abnormal and normal plasma cells

Question 19

Crab

Answer 19

Calcium
Renal
Anemia
Bone

Question 20

Gemcitabine applications

Answer 20

Lung and pancreatic cancer

Question 21

Bortzomib

Answer 21

Antibprotease used to treat multiple myeloma

Side effects are neuropathy- this is decreased with subcutaneous admin

Question 22

Cyclophoride applications

Answer 22

Breast, osteosarcoma, lymphoma

Question 23

Cyclophoride side effects

Answer 23

Mylisuppresikn
GI
Diahrrea
Cystitis because of accumulation of the chemical in the bladder

Question 24

ERCC1

Answer 24

DNA repair enzyme

Increased for cisplatin resistance

Question 25

14q32

Answer 25

Most common mutation in multiple myeloma

Question 26

Plerixafor

Answer 26

Used to increase stem cells in peripheral blood | CDCR - SDF-1 antagonist

Question 27

Cetuximab

Answer 27

Outside EGFR antibody | Lung cancer

Question 28

Panitumumab

Answer 28

Outside EGFR antibody | Lung cancer

Question 29

Erlotinib

Answer 29

Block internal tyrosine kinase activity of EGFR

Question 30

Gefitinib

Answer 30

Blocks internal tyrosine kinase activity

Question 31

Trastuzumab

Answer 31

Antibody that blocks outside tyrosine kinase activity of her2

Question 32

Pertuzumab

Answer 32

Blocks dimerizarikn of her2

Question 33

Lapatinib

Answer 33

Blocks internal tyrosine kinase activity of her2

Question 34

Bevacizumab

Answer 34

Blocks extra cellular domain of VEGF

Question 35

Sorafinib

Answer 35

Blocks internal tyrosine kinase activity of VEGF

Question 36

Sunitinib

Answer 36

Blocks internal tyrosine kinase activity of VEGF

Question 37

Diffuse large B cell lymphoma mutation

Answer 37

3q27 | BCL-6

Question 38

FL markers

Answer 38

Cd10 | Bcl2

Question 39

Most common lymphomas

Answer 39

Dlbcl most common | Fl 2nd

Question 40

9:22

Answer 40

Philadelphia chromosome

Question 41

Imatinib

Answer 41

Displaces ATP from Phillinchormoske

Question 42

Burkitts Chromosome mutation

Answer 42

8:14

Question 43

Mantle cell lymphoma mutation

Answer 43

11:14

Question 44

T cell inhibitory interaction

Answer 44

B7-CLTA4

Question 45

Excitatory T cell interaction

Answer 45

B7- CD28

Question 46

Most common adult acute leukemia

Answer 46

aml

Question 47

Xerostomia

Answer 47

Dry mouth

Question 48

Bliomyosin toxicity

Answer 48

Pulmonary fibrosis

Question 49

Adriamycin side effect

Answer 49

Cardiac toxicity

Question 50

CD43

Answer 50

Mantle cell