HEMA Flashcards
(17 cards)
Treatment for HIT
Discontinue Heparin!
If pt need anticoagulation: may use Argatroban and lepirudin ( direct thrombin inhibitors), Danaparoid (glycosiaminoglycans with anti-Xa activity: effective in HIT
Anticoagulation strongly considered even in the absence of thrombosis: warfarin 3-6 mos
Secondary cause of ITP
SLE, infection Hiv and Hep C
PBS of ITP
Large plt with other wise normal morphology
Treatment for ITP
If without significant bleeding may treat as outpatient: prednisone at 1mg/kg, immune globulin therapy (winRho SDF)at 50-75ug/kg
IvIg blocks the FC receptor system
In hospital: IVIG or antiRho + hig dose Gc
Rituximab treatment for refrectory ITP
Splenectomy
Eltrombopag and romiplostim for refractory ITP
Pentad of TTP
Thrombocytopenia
Microangiopathic hemolytic anemia
Renal failure
Neurologic findings
Fever
Medication related microangiopathic hemolytic anemia due to antibody formation
Ticlopidine
Possible clopidogrel
Medication related microangiopathic hemolytic anemia due to direct endothelial toxicity
Cyclosporine
Mitomycin C
Tacrolimus
Quinine
PBS of TTP
Schistocytes polychromasia, nucleated RBC
Mainstay treatment of TTP
Plasma exchange
Adjunct: GC
HUS CHARACTERISTICS
Acute renal failure; microangiopathic hemolytic anemia
Thrombocytopenia
Most frequent cause of HUS
E coli O157:H7
Most common inherited bleeding disorder
Vwd
Most common type of VWF disease
Type 1
Presentation: Menorrhagia, excessive bruising and epistaxis.
Mild type 1: frequent bleedung with dental extraction or tonsillectomy
Treatment for VWD
TYpe 1: DDAVP
Also effective in type 2A and 2M
Mature T cell disorder, with generalized erythroedema and circulating tumor cells + lymphadenopathy
Sezary Syndrome
Treatment ALL T(9:22) (q34;q11.2)
ALL T(9:22) (q34;q11.2) is Philadelphia +
Dasatinib +Chemo
Treatment for Angioimmunoblastic T Cell lymphoma and what us the most common mutation found
CHOP chemotherapy 15-36 months
TET2
