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1

Average volume per cell, expressed in femtoliters.

Mean cell volume (MCV)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 423

2

A reduction in the oxygen-transporting capacity of blood.

Anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 422

3

The average content of hemoglobin per red cell, expressed in picograms.

Mean cell hemoglobin (MCH)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 423

4

The average concentration of hemoglobin in a given volume of packed red cells, expressed in g/dL.

Mean cell hemoglobin concentration (MCHC)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 423

5

The coefficient of variation of red cell volume.

Red cell distribution width (RDW)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 423

6

Anemia of acute blood loss is described as ______.

Normocytic, normochromic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 423

7

Life span of a normal red cell.

120 days(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424

8

Anemia characterized by an increased rate of cell destruction, a compensatory increase in erythropoeisis that results in reticulocytosis, and retention of products of cell destruction, including iron.

Hemolytic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424

9

A circulating protein that binds and clears free hemoglobin.

Haptoglobin(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424

10

Hemolysis that can result from mechanical trauma, or biochemical or physical agents that damage the red cell membrane.

Intravascular hemolysis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424

11

Hemolysis which takes place largely within phagocytic cells of the spleen and liver.

Extravascular hemolysis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424

12

This disorder is characterized by an intrinsic defect in the red cell membrane, that renders the cells spheroidal, less defomable and vulnerable to splenic sequestration and destruction.

Hereditary spherocytosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424

13

Small, dark nuclear remnants seen within red cells in PBS of hereditary spherocytosis.

Howell-Jolly bodies(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 425

14

On PBS, red cells are spherical which lack central pallor, and they show increased osmotic fragility when placed in hypotonic salt solutions.

Hereditary spherocytosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 425

15

Structural proteins that are defective in hereditary spherocytosis.

Spectrin and ankyrin(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 425

16

This results from substitution of valine for glutamic acid at the 6th position of the B-chain, producing HbS.

Sickle cell anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 426

17

Bizarre, elongated, spindled or boat-shaped cells on PBS.

Sickel cell anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 427

18

Prominent cheekbones and changes in skull resembling a "crew-cut" skull x-ray.

Sickle cell anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 427

19

Patients with sickle cell disease are predisposed to infections caused by these type of bacteria.

Encapsulated bacteria(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 428

20

Treatment for sickle cell disease by increasing levels of HbF.

Hydroxyurea(TOPNOTCH)

21

Treatment for sickle cell disease by increasing levels of HbF.

Hydroxyurea(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 428

22

Feared complication of sickle cell disease which can be trigerred by pulmonary infections or fat emboli from necrotic marrow that secondarily involve the lung.

Acute chest syndrome(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 428

23

Major complication of sickle cell disease which occurs in the setting of acute chest syndrome, causing ischemic injury to the CNS.

CNS stroke(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 428

24

Represents a sudden but usually temporary cessation of erythropoeisis, usually trigerred by parvovirus B19 infections in patients with sickle cell disease.

Aplastic crises(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 428

25

In beta thalassemia, an individual who inherits one abnormal allele (out of 2) has this asymptomatic to mildly symptomatic condition.

B- Thalassemia minor/trait(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 429

26

Individuals with B-thalassemia who inherit two abnormal alleles, with severe anemia requiring regular blood tranfusions.

B- Thalassemia major(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 429

27

Red cells with a central, dark-red puddle due to collection of hemoglobin.

Target cells(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 430

28

Target cells are often seen in this condition.

B-thalassemia minor(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 430

29

In the PBS of this condition, nucleated red cells (normoblasts) are seen, which reflect underlying erythropoeisis.

B-thalassemia major(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 430

30

Anemia of beta thalassemia.

Microcytic, hypochromic(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 430