hematologic alteratations Flashcards
(39 cards)
Primary regulatory hormone for red cell
production
EPO
Organ responsible for red cell production
Erythron
8 μm in diameter, anucleate, discoid
in shape, and extremely pliable in order to traverse
the microcirculation successful
mature red cells
male anemic
<130g/L
female anemic
120g/L
10-15% blood loss (500-700ml)
hypotension and decreased organ perfusion
> 30%(1500ml)
postural hypotension*, tachycardia
hypovolemic shock including confusion, dyspnea, diaphoresis, hypotension, and tachycardia
> 40%
Palmar crease – full palm is very pale or is as pale
as its surrounding areas; when this occurs the Hgb is
already ____
<7g/dL or <70g/L
ACUTE HEMOLYSIS
o Acute back pain
o Free hemoglobin in the plasma and urine
o Renal failure
Hemoglobin<70-80 g/L
severe anemia
severe anemia tx
blood transfusion
If the cause of anemia is acute blood
loss, the red cell production rate
increases (positive feedback)
A reticulocyte response less than two to three
times normal indicates an
inadequate marriw response
reflects absolute or relative marrow failure
hypoproliferative
Ri >= 2.5
Hemolysis/ hemorrhage
Is defined as an increase in the hemoglobin above
normal. This increase may be real or only apparent
because of a decrease in plasma volume (spurious or
relative)
POLYCYTHEMIA
Petechiae pin point red rashes
Low counts of platelets
loss of 80> cc of blood per
cycle
menorrhagia
Normal platelet count:
150,000-350,000/μL
thrombocytopenia platelet count
<100,000/μL
a measurement of platelet
function, is abnormally increased if platelet
count is <100,000/μL; injury or surgery may
provoke excess bleeding
bleeding time
Thrombocytopenia- dengue
Increased destruction
Clopidogrel is avoided
I wk to 10 days