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PHARMACOLOGY 2 - HEMATOLOGIC LESSON 1 > Hematologic Lesson 1 - DRUGS > Flashcards

Hematologic Lesson 1 - DRUGS Flashcards

(72 cards)

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1
Q

What is the therapeutic range/ heparin level for aPTT (acitivated partial thrombosplatin time)

A

1.5 to 2.5 times the control value (about 30-80 seconds)

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2
Q

What is the therapeutic range/heparin level for Protamine titration?

A

0.2 to 0.4 unit/mL

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3
Q

What is the therapeutic range/heparin level for Anti-Xa units?

A

0.3 to 0.7 unit/mL

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4
Q

What is the INR range for DVT/PE?

A

2.0 to 3.0

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5
Q

What is the INR range for Atrial Fibrillation?

A

2.0 to 3.0

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6
Q

What is the INR range for Myocardial Infraction?

A

2.0 to 3.0

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7
Q

What is the INR range for Mechanical Heart Valves?

A

2.5 to 3.5

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8
Q

Drugs for Enzyme induction in pharmacokinetic effects

A
  1. Barbiturate
  2. Rifampin
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9
Q

Drugs for Enzyme inhibition in pharmacokinetic effecrts

A
  1. Cimetidine
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10
Q

Drugs for reduced plasma protein binding in pharmacokinetic effects

A
  1. Phenylbutazone
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11
Q

Impaired hemostasis,
reduced clotting factor synthesis, as in
hepatic disease

A

Synergism

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12
Q

Vitamin K

A

Competitive antagonism

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13
Q

Hereditary resistance to oral anticoagulants

A

An altered physiologic control loop for
vitamin K

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14
Q

What are the drugs under the prevention of embolic stroke in patients with nonvalvular atrial fibrilation

A
  1. Apixaban
  2. Edoxaban
  3. Rivaroxaban
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15
Q

What are the drugs under the prevention of venous thromboembolism followwing hip or knee surgery

A
  1. Apixaban
  2. Rivaroxaban
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16
Q

What are the drugs under the treatment of venous thromboembolic disease (VTE)

A
  1. Apixaban
  2. Edoxaban
  3. Rivaroxaban
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17
Q

First antidote approved
for use in patients treated with anti-Xa
agents who require rapid reversal for
surgery or uncontrolled bleeding

A

Andexanet alfa

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18
Q

Drugs under Parenteral Direct Thrombon Inhibitors

A
  1. Hirudin
  2. Lepirudin
  3. Bivalirudin
  4. Argatroban
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19
Q

Irreversible thrombin inhibitor
from leech saliva

A

Hirudin

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20
Q

Recombinant form of Hirudin

A

Lepirudin

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21
Q

With a rapid onset and offset of action

A

Bivalirudin

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22
Q

Given by continuous IV
infusion due to short half-lifeaPTT

A

Argatroban

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23
Q

Drugs under Oral Direct Thrombin Inhibitor

A

Dabigatran etexilate mesylate

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24
Q

Rapid onset and offset of action allow
immediate anticoagulation

A

Dabigatran etexilate mesylate

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25
Use in patients with thrombosis related to heparin-induced thrombocytopenia
Lepirudin
26
FDA-approved for use in percutaneous coronary angioplasty
Bivalirudin
27
FDA-approved for use in patients with HIT with or without thrombosis and coronary angioplasty in patients with HIT
Argatroban
28
Approved for use in Europe for prevention of venous thromboembolism in patients who have undergone hip or knee replacement surgery
Dabigatran
29
Monitored by aPTT
1. Lepirudin 2. Argatroban
30
PTT, thrombin time, and ecarin clotting time [(ECT)
Dabigatran
31
Clotting test based on the use of a protein isolated from viper venom] can be use to estimate drug effect
Dabigatran
32
Humanized monoclonal antibody Fab fragment binds to dabigatran and reverses the anticoagulant effect
Idarucizumab
33
Approved for use in situations requiring emergent surgery or for life-threatening bleeding
Idarucizumab
34
Drugs under GP IIb/IIIa receptor antagonist
1. Abciximab 2. Eptifibatide 3. Tirofiban
35
Drugs under ADP receptor antagonist
1. Ticlopidine 2. Clopidogrel 3. Prasugrel
36
Drugs under TXA2 (COX) inhibitor
Aspirin
37
Drugs under PDE/ adenosin uptake inhibitor
1. Dipyridamole 2. Cilostazol
38
What is the mechanism of action of aspirin under Antithrombotic?
Inhibits COX, thus prevents TXA2 (a potent platelet aggregating substance) and PGs formation
39
What is the mechanism of action of Clopidogrel and Ticlopidine under Antithrombotic?
Inhibit ADP pathway of platelet formation
40
What is the mechanism of action of Dipyridamole under Antithrombotic?
Inhibits platelet function by inhibiting adenosine uptake and cGMP phosphodiesterare (PDE) activity
41
What is the mechanism of action of Cilostazol under Antithrombotic?
Phosphodiesterase (PDE) inhibitor that promotes vasodilation and inhibition of platelet aggregation
42
What is the mechanism of action of Abciximab, Eptifibatide and Tirofiban under Antitrombotic?
Inhibit GP IIb/IIIa, a glycoprotein receptor molecule necessary for platelet aggregation
43
A fat-soluble substance found primarily in leafy green vegetables
Vitamin K
44
A drug found in food
Vitamin K1 (Phytonadione)
45
A drug found in human tissues and is synthesized by intestinal bacteria
Vitamin K2 (Menaquinone)
46
It is currently administered to all newborns to prevent the hemorrhagic disease
Vitamin K1
47
How many hours does vitamin K1 can delayed onset effect
6 hours
48
How many hours is the complete effect of Vitami K1 when treating depression of prothrombin activity caused by excess warfarin or vitamin K deficiency
24 hours
49
What are the available administration for vitamin K1?
Oral adn parenteral forms
50
Intravenous administration of vitamin K1 should be slow, if rapid infusion occurs it can produce what?
1. Dyspnea 2. Chest pain 3. Back pain 4. Death
51
It is best achieved with intravenous or oral administration because its bioavailability after subcutaneous administration is erratic
Vitamin K repletion
52
It is used for the treatment of Warfarin overdosage and Vitamin K deficiency
Vitamin K
53
Water soluble; ineffective in warfarin overdosage
Vitamine K3 (Menadione)
54
It is frequently occurs in hospitalized patients in intensive care units because of poor diet, parenteral nutrition, recent surgery, multiple antibiotic therapy, and uremia
Vitamin K deficiency
55
Used as a treatment of blood clotting factors deficiencies
Plasma Fractions
56
Factor VIII deficiency
1. Classic hemophilia 2. Hemophilia A
57
Factor IX deficiency
1. Christmas disease 2. Hemophilia B
58
Factors under plasma fractions
1. Factor VIII deficiency 2. Factor IX deficiency 3. Lyophilized factor VIII
59
A factor VIII-Fc domain conjugate that prolongs the factor VIII half-life and allows twice-weekly dosing
Eloctate
60
A factor IX-albumin conjugate with a half-life of 100 hours
Idelvion
61
FDA-approved for prophylaxis or treatment of bleeding in hemophilia B patients
Idelvion
62
A factor VIII concentrate approved by the FDA for the treatment of bleeding associated with von Willebrand disease
Humate-P
63
A recombinant von Willebrand factor product approved for treatment and control of bleeding in adults with von Willebrand disease
Vonicog alfa
64
Used for factor deficiencies for which no recombinant form of the protein is available
Fresh frozen plasma
65
A four-factor plasma replacement preparation containing vitamin K–dependent factors II VII, IX, and X
4F PCC (Kcentra)
66
For rapid reversal of warfarin in bleeding patients
4F PCC (Kcentra)
67
Increases the factor VIII activity of patients with mild hemophilia A or von Willebrand disease
DESMOPRESSIN ACETATE
68
Can be used in preparation for minor surgery such as tooth extraction and available in high-dose intranasal desmopressin
DESMOPRESSIN ACETATE
68
Can be used in preparation for minor surgery such as tooth extraction and available in high-dose intranasal desmopressin
DESMOPRESSIN ACETATE
69
Plasma protein fraction obtainable from whole blood
CRYOPRECIPITATE
70
Used to treat deficiencies or qualitative abnormalities of fibrinogen
CRYOPRECIPITATE
70

PHARMACOLOGY 2 - HEMATOLOGIC LESSON 1 (2 decks)

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