Hematologic Malignancies Flashcards
(7 cards)
1
Q
When should you suspect hematologic malignancies?
A
1) Unexplained fevers lasting longer than typical viral infections
2) Cranial nerve palsies, abnormal gait, loss of coordination
3) Abdominal distention
4) Fatigue, weight loss
5) Anemia in a post pubertal male
2
Q
What are the 4 bone marrow failure syndromes?
A
1) Aplastic anemia
2) PNH (Paroxysmal Nocturnal Hematuria)
3) MDS (Myelodysplastic Syndrome)
4) AML
3
Q
MDS (Myelodysplastic Syndrome) is defined as:
A
Dysplastic bone marrow changes = Increased blast population
4
Q
Congenital Bone marrow failure syndromes predispose to:
A
AML
5
Q
Translocation in AML-M3?
A
t(15;17)
6
Q
APML or AML-M3 can be cured with:
A
ATRA ( all trans retinoic acid)
7
Q
A
