Hematologic Malignancies

Question 1

Major types of malignancies

Answer 1

Leukemias
Lymphomas
Multiple Myeloma

Question 2

Types of Leukemia

Answer 2

Acute Myelogenous Leukemia (AML)
Acute Promyelocytic Leukemia (APL)
Acute Lymphocytic Leukemia (ALL)
Chronic Myelogenous Leukemia (CML)
Chronic Lymphocytic Leukemia (CML)

Question 3

Types of Lymphomas

Answer 3

Hodgkin’s Disease

Non-Hodgkin’s Disease

Question 4

An unregulated proliferation of myeloid line proginator cells (blasts)

Answer 4

AML

• Proliferating blasts inhibit normal cellular maturation in bone marrow
• More common in males
• Any age (median 67)

Question 5

S/S of ____ are:

Malaise, bone pain, fever, gum hypertrophy, CNS (seizures, HA, visual dist)-more common in ___.

Answer 5

AML

CNS more common in ALL

Question 6

Very important diagnostic tool for detecting cancer

Answer 6

Bone marrow biopsy
Normal marrow has 5% blasts
Leukemia has more than 20%
FISH (fluorescent in situ hybridization)

Question 7

Unregulated proliferation of myeloid line progenitor cells (blasts) that inhibit normal cellular maturation in bone marrow

Answer 7

Acute Myeloid Leukemia (AML)

Question 8

Untreated AML can result in

Answer 8

Death in 2-3 months

Question 9

AML population

Answer 9

Any age, median 67

Males more common

Question 10

S/S of AML

Answer 10

Malaise
Bone Pain
Fever
Gum Hypertrophy 
CNS (more common in ALL)
  -seizures, HA, visual disturbances