HEMATOLOGIC NEOPLASMS

Question 1

Comprises 5% AML
[2]

Answer 1

FAB M0 Actue Myeloid Leukemia, Minimally Differentiated

FAB M3 Acute Promyelocytic Leukemia

Question 2

FAB M0 [AML, MINIMALLY DIFFERENTIATED]

[+/-] AUER RODS

Answer 2

NEGATIVE

Question 3

NEGATIVE MPO, SBB

Answer 3

FAB M0

Question 4

IMMUNIPHENOTYPING: CD13, CD33, CD34,117

Answer 4

M0 AML, MIN. DIFFERENTIATED
M1 AML, W/O MATURATION
M2 AML, W/ MATURATION

Question 5

NO CELLULAR MATURATION EVIDENCE

Answer 5

AML, MIN. DIFFERENTIATED M0

Question 6

> 90% MYELOBLASTS
</> 10% LEUKOCYTES SHOW MATURATION TO THE PROMYELOCYTE STAGE

Answer 6

ACUTE MYELOID LEUKEMIA, W/O MATURATION

Question 7

PRESENCE OF AUER RODS

PRESENCE OF AUER RODS [BUNDLES-FAGGOT CELLS]

Answer 7

FAB M1 AML, MIN. DIFFERENTIATED
FAB M2 AML, W/O MATURATION
FAB M4 ACUTE MONOMYELOCYTIC LEUKEMIA

FAB M3 AML, W/ MATURATION

Question 8

POSITIVE FOR MPO, SBB, CAE

Answer 8

FAB M1 AML, W/O
FAB M2 AML, W/
FAB M3 PROMYELOCYTIC

Question 9

PRESENCE OF CHLOROMA (green appearance of tissue using MPO)

Answer 9

FAB M1 W/O

Question 10

ACCOUNTS FOR 50% of AML CASES

Answer 10

FAB M1/M2

Question 11

90% MYELOBLASTS
10% MATURING NEUTRO LINEAGE
20% PRECURSORS W/ MONOCYTIC LINEAGE

Answer 11

FAB M2, W/

Question 12

AML, W/ MATURATION [FAB M2]
genetic translocation:

Answer 12

t(8;21) (q22;q22.1)
RUNX1/ RUNX1T1

Question 13

genetic translocation of Acute Promyelocytic Leukemia [FAB M3]

Answer 13

BALANCED TRANSLOCATION:
t(15;17)
PML gene - RaRa gene= PML-RaRa

Question 14

+30% ABNORMAL PROMYELOCYTES

2 TYPES:
1.
associated w/ [diseases + results{

2. /
   [nucleus appearance]

Answer 14

Hypergranular
DIC +
HLA -

Hypogranular/Microgranular
“butterly” coin-on-coin appearance

Question 15

FAB M3 Treatment

Answer 15

all-trans-retinoic acid
arsenic trioxide (ATRA)

Question 16

NAEGELI’S TYPE

Answer 16

FAB M4
ACUTE MYELOMONOCYTIC LEUKEMIA

Question 17

FAB ___— FAB M4 variant w/ myeloblasts + monoblasts + _________

Answer 17

FAB M4Eo
Abnormal Eosinophils

Question 18

> 30% of AML Cases

Answer 18

FAB M4, ACUTE PROMYELOCYTIC LEUKEMIA

Question 19

> 30% of AML CASES

> 20% WHO / >30% FAB: MARROW MYELOBLASTS

> 20% to __%: MONOCYTIC REGION

_______

Answer 19

80%

FAB M4

Question 20

MONOCYTIC IMMUNOPHENOTYPING FOR FAB M4

Answer 20

CD4, CD 11b/c, CD 14/64, CD 36, CD 68, LYZOZYME

Question 21

POSITIVE FOR MPO, SBB, CAE + NSE

Answer 21

FAB M4

Question 22

FAB M5 CYTOGENETIC ABN:

Answer 22

t(8;16) p(11;13) + M5/M4

Question 23

COMPRISES 10% of AML CASES

Answer 23

FAB M5

Question 24

FAB M5 is divided into 2 TYPES dependent on the degree of maturity:

1. BM%___[children/adult]
2. BM%___[children/adult]

Answer 24

1. FAB M5a
   Schilling’s Type
   AML w/o maturation
   AML poorly undifferentiated

> 80% children

2.
FAB M5b
AML w/ maturation
AML well-differentiated

<80% adults (middle-aged)

Question 25

WHAT FAB IS THIS: CD4, CD11b, CD11c, CD14, CD 64

Answer 25

FAB M5

Question 26

POSITIVE FOR NSE

Answer 26

FAB M4 MYELOMONOCYTIC FAB M5 MONOCYTIC

Question 27

ABN, COMPRISING CYTOGENETIC TRANSLOCATION OF chromosome 8 short-arm 11 to chromosome 16 short-arm 13

Answer 27

FAB M5

Question 28

DISEASE PRESENT IN ACUTE ERYTHROLEUKEMIA ____ FAB M__

Answer 28

Di Guglielmo’s Syndrome FAB M6

Question 29

>50% DYSPLASTIC NARROW NORMOBLASTS FAB M__

Answer 29

FAB M6

Question 30

>50% DYSPLASTIC NARROW NORMOBLASTS FAB M__ [PURE/ ACUTE]

Answer 30

FAB M5

Question 31

>80% ERYTHROID CELLS (RBC) >30% PROERYTHROBLASTS FAB M__ [PURE/ ACUTE]

Answer 31

6 PURE

Question 32

Acute Erythroleukemia [2 Morphological Abn]

Answer 32

Ringed sideroblasts Howell-Jolly Bodies

Question 33

WHAT FAB IS THIS: CD 13, CD 15, CD33, CD 117

Answer 33

ACUTE ERYTHROLEUKEMIA FAB M6

Question 34

POSITIVE FOR PAS

Answer 34

FAB M6 ACUTE ERYTHROLEUKEMIA FAB M7 ACUTE MEGAKARYOBLASTIC LEUKEMIA

Question 35

FAB M6 IMMUNOPHENOTYPING ERYTHROBLASTS:

Answer 35

CD 45, CD 71 [GLYCOPHORIN A]

Question 36

RAREST AML

Answer 36

ACUTE MEGAKARYOBLASTIC LEUKEMIA FAB M7

Question 37

HAS __% MEGAKARYOCYTIC ORIGIN FAB M__

Answer 37

50 7

Question 38

FAB M7 ACUTE MEGAKARYOBLASTIC LEUKEMIA IMMUNOPHENOTYPING:

Answer 38

CD 41[gpIIb] CD 42 [gbIb] CD 61 [gpIIIa] vWF

Question 39

CD MARKERS associated with 1. gpIIb : 2. gpIa :

Answer 39

CD 41 CD 61

Question 40

POSITIVE FOR Alpha Naphthyl acetate esterase

Answer 40

FAB M7 ACUTE MEGAKARYOBLASTIC LEUKEMIA