Hematology Flashcards
(20 cards)
Low ESR
PV
Leucocytosis
Sickle cell
JAK2V617F
PV
ET
PMF
Microcytic with erythrocytosis
Beta thal
Hypoxic erythrocytosis
PV
Drug that shrinks spleen
Peg INF alpha
Leucostatic manifestation due to severe leucocytosis or thrombocytosis
- Vaso occlusive disease
- CVA
- MI
- Venous thrombosis
- Priapism
- Visual disturbance
- Pulmonary insufficiency.
Sokal index
Px in CML
Age Blasts in circulation Count platelet Splenomegaly Cytogenetic abN
M:E increased
CML
Leukemoid reaction
M:E decreased
Hemolytic anemia
Megaloblastic anemia
Normal M:E ratio in pathology
Anaplastic anemia
Myelosclerosis
Conditions where patient may have CRF with enlarge kidney size are:
a. Diabetes
b. Polycystic kidney
c. Amyloidosis
d. Multiple Myeloma
e. Bilateral hydronephrosis
POEMS syndrome in MM
Osteosclerotic myeloma associated with Polyneuropathy Organomegaly Endocrinopathy Monoclonal gammopathy Skin changes
MPN with no hepatomegaly, no splenomegaly and no lymph adenopathy.
In MM there is no hepatomegaly, no splenomegaly and no lymph adenopathy.
b. CHF is not a feature of MM.
MPN WITH no hepatomegaly, no splenomegaly and no lymph adenopathy.
In MM there is no hepatomegaly, no splenomegaly and no lymph adenopathy.
b. CHF is not a feature of MM.
Triad of MM
- BM plasmacytosis >10% 2. Lytic lesion in the bones in X-ray 3. Urine or plasma M components
Conditions with decreased ESR
- Polycythemia vera
- CHF
- Sickle cell anemia
- Afibrinogenemia
Conditions with increased ESR that need to be remembered:
- Multiple myeloma
- Anemia other than sickle cell
- Giant cell arteritis
- De Quervain thyroiditis
MGUS Complications
i. Solid tumours.
ii. Lymphomas
iii. Amyloidosis
iv. Chronic lymphatic leukemia
Triad of hairy cell leukemia
a. Massive splenomegaly
b. Pancytopenia
c. Vasculitis
like syndrome i.e. Erythema Nodosum, Cutaneous nodules
Subacute cerebellar degeneration
a. Small cell carcinoma lung
b. Thymoma
c. Neuroblastoma
Causes of MAHA
a. HUS
b. TTP
c. Prosthetic Metallic valve
d. Malignant Hypertension
