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ABR > Hematology > Flashcards

Hematology Flashcards

(53 cards)

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1
Q

Low iron
Low trans sat
High TIBC
Low ferritin

A

Iron deficiency

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2
Q

Low iron
Low/normal trans sat
Low TIBC
High ferritin

A

Anemia of inflammation

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3
Q

High iron
High trans sat
Low TIBC
Very high ferritin

A

Hemochromatosis

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4
Q

Staining of iron in macrophages and NO RBC staining

A

Anemia of inflammation

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5
Q

Thallasemia

Southeast Asian

A

Alpha thallasemia

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6
Q

Thallasemia

Mediterranean

A

Beta Thallasemia

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7
Q

High HbA2

A

Beta thallasemia

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8
Q

Diagnose alpha Thallasemia

A

DNA PCR analysis

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9
Q

Diagnose Beta thallasemia

A

Hgb electropharesis

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10
Q

High Hgb S

Rest Hb A

A
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11
Q

High Hb S
Low Hb F
Very low HBA2

A

Sickle cell anemia

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12
Q

Point mutation is Sickle cell disease

A

Glutamate to Valine

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13
Q

Management for acute chest syndrome

A

Exchange transfusion

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14
Q

Management for priapism in sickle cell

A

<4 hr: intracavernosal phenyleophrine

>4hr: aspiration. Then surgical fistula between cavernosum and spongiosum. If fails, exchange transfusion

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15
Q

Most common a cause of osteomyelitis in sickle cell

A

Salmonella

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16
Q

High Hb A

Rest Hb A and F

A

Beta Thallasemia trait

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17
Q

Low Hb A

Rest Hb A2 and F

A

Beta Thallasemia major

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18
Q

High Hb A
Some Hb S
Low Hb A2 and F

A

Sickle cell trait

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19
Q

High Hb S
Some Hb F
Low Hb A2

A

sickle cell disease

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20
Q

High Hb S
Some Hb F and A2
Low HbA

A

Sickle/thal

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21
Q

Increased MMA

A

B12 deficiency

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22
Q

Increased homocysteine

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A

B12, folate, B6 deficiency

23
Q

Treatment for 5q gene deletion

24
Q

Indication for irradiated pRBC

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A

Prevention of associated GVHD

25
Uremia Anemia Burr cells
Anemia if uremia
26
IV nitrates | Cyanosis
Methemoglobinemia
27
Hemolytic anemia IgG SLE, CLL, Ceftriaxone Spherocytes Management
Warm autoimmune hemolytic anemia (direct) Steroids Rituximab
28
Hemolytic anemia IgM Mono, flu, mycoplasma Management
Cold autoimmune hemolytic anemia Avoid cold
29
Abdominal pain Mesenteric vein thrombosis Diagnostic test Management
Paroxysmal nocturnal hemoglobinuria DAF assay/Flow cytometry if CD55/59 Eculizumab
30
Smoker. Alcohol. Barbiturates. OCPs | Dark red urine. No blood
Acute intermittent porphyria | PBG deaminase deficiency
31
Uroporphyrinogen decarboxylase deficiency
Porphyria cutaneous tarda
32
Positive eosin-5-maleimide binding test
Cytoskeleton spectrin membrane defect | Hereditary spherocytosis
33
Blood transfusion Febrile. Restless. Dyspneic Dark red urine Hgb drops
Major hemolytic reaction (early) | ABO incompatibility
34
Blood transfusion | Dark urine a week later
Late hemolytic reaction | Rh incompatibility
35
Indication for washed RBC transfusion
History of urticaria and allergies | History of IgA deficiency
36
Blood transfusion Fever/chills No drop in Hgb
Febrile nonhemolytic reaction
37
Indication for leukocyte-reduced pRBC
Prevention of febrile nonhemolytic reaction
38
Blood transfusion | Anaphylaxis
IgA deficiency
39
Blood transfusion Respiratory distress Normal JVP
TRALI
40
Blood transfusion Respiratory distress Elevated JVP
TACO
41
Universal donor
O-
42
Universal recipient
AB+
43
Abnormal platelet aggregation
Glanzmann’s disease
44
Bleeding with herbal meds
Ginkgo biloba | Ginseng
45
Low ristocetin cofactor assay
Von willebrand disease
46
Reversal for Dabigatran
Idarucizumab
47
Management for polycythemia Vera
Phlebotomy to keep Hct < 45% Hydroxyurea Low dose ASA
48
Management for essential thrombocytosis
Low dose ASA | hydroxyurea if DVT or Age > 60 + plt > 1mil
49
Philadelphia chromosome
t(9;22) Bcr/abl CML
50
t(15;17)
Acute promyelocytic leukemia | Auer rods
51
Febrile neutrophilic dermatosis
Sweets syndrome.
52
Smudge cells
CLL
53
Hairy cells Splenomegaly Management
Hairy cell leukemia Cladribine

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