Hematology

Question 0

What is the most common microcytic anemia?

Answer 0

Iron deficiency anemia

Question 1

What is the normal range for MCV?

Answer 1

80-100

Question 2

What two main causes should you be thinking of in a macrocytic anemia?

Answer 2

Malnutrition and severe blood loss

Question 3

Auer rods are most commonly associated with what disease?

Answer 3

Acute myeloid leukemia

Question 4

What molecule binds iron in the bloodstream?

Answer 4

Transferrin

Question 5

What does koilonychia refer to?

Answer 5

Spoon shaped nails. This may be found in microcytic anemia.

Question 6

A low retic count and a normal serum ferritin should make you think of what diagnosis?

Answer 6

Anemia of chronic disease

Question 7

Under normal conditions at what hemoglobin level would you began to consider a transfusion?

Answer 7

8

Question 8

Which anemia should you think of if you see the term Howell-Jolly bodies?

Answer 8

Sickle cell due to functional asplenia, but it may also show up in folic acid deficiency.

Question 9

G6PD deficiency follows what pattern of inheritance?

Answer 9

X-linked

Question 10

List the three diagnosis you should be thinking of if a question includes Heinz bodies?

Answer 10

G6PD deficiency anemia, chronic liver disease, alpha thalassemia

Question 11

Are target cells seen in mild or severe iron deficiency anemia?

Answer 11

Severe, they are also seen in alpha thalassemia, chronic liver disease and asplenia.

Question 12

Iron deficiency anemia will have a serum iron lower than what value?

Answer 12

30

Question 13

You should be thinking alpha thalassemia if the question stem includes which four geographic areas?

Answer 13

Southeast Asia, China, Middle East, Africa

Question 14

A patient of Mediterranean descent is a clue for which type of anemia?

Answer 14

Beta thalassemia

Question 15

In a folic acid deficiency anemia the folic acid level is typically below what level?

Answer 15

<150

Question 16

The term Philadelphia chromosome should make you think of what diagnosis?

Answer 16

Chronic myeloid leukemia

Question 17

WBC

Answer 17

4-11 (Medscape)

Question 18

Hb

Answer 18

14-17.5 men

12.3-15.3 women (Medscape)

Question 19

Hct

Answer 19

40-54% men

36-46% women (Medscape)

Question 20

Platelets

Answer 20

150,000-450,000 (Hopkins)

Question 21

Thalassemias

Answer 21

Microcytosis, target cells
A2 or F in beta-thalassemia
Electrophoresis

Question 22

Multiple myeloma

Answer 22

Bone pain, fx & hypercalcemia MC findings

Bence-Jones proteins

Question 23

Schilling test was to?

Answer 23

Determine the cause of B12 deficiency

Question 24

Reed-Sternberg cells

Answer 24

Hodgkin Lymphoma Painless lymphadenopathy Peak 20s or >50 Most patients present w/ painless mass, commonly in neck

Question 25

Christmas disease

Answer 25

Hemophilia B (factor IX hemophilia) Hereditary bleeding disorder. Managed w/ factor IX concentrates or FFP

Question 26

Heparin-induced thrombocytopenia

Answer 26

Thrombosis occurs in 50% of cases; | Bleeding is uncommon

Question 27

Is sickle cell microcytic, macrocytic or normocytic?

Answer 27

Microcytic

Question 28

List four disease states in which you may find basophilic stippling.

Answer 28

Lead poisoning, Beta or alpha thalassemia, sideroblastic anemia, arsenic poisoning.