Hematology Flashcards Preview

Step 1 Pharm > Hematology > Flashcards

Flashcards in Hematology Deck (62):
1

heparin

d

2

enoxaparin

d

3

dalteparin

d

4

fondaparinux

d

5

argatroban

b

6

bivalirudin

d

7

dabigatran

d

8

warfarin

d

9

apixaban

d

10

rivaroxaban

d

11

alteplase (tPa)

Thrombolytic

12

reteplase (rPa)

thrombolytic

13

streptokinase

thrombolytic

14

tenecteplase TNK-tPA

thrombolytic

15

Aspirin

COX inhibitor

16

clopidogrel

ADP receptor inhibitor

17

prasugrel

ADP receptor inhibitor

18

ticagrelor

ADP receptor inhibitor

19

ticlopidine

ADP receptor inhibitor

20

cilostazol

phosphodiesterase III inhibitor

21

dipyridamole

phosphodiesterase III inhibitor

22

abciximab

GP IIb/IIIa inhibitor

23

eptifibatide

GP IIb/IIIa inhibitor

24

tirofiban

GP IIb/IIIa inhibitor

25

azithioprine

purine thiol analog

26

6-mercaptopurine (6-MP)

purine thiol analog

27

6-thioguanine

purine thiol analog

28

Cladribine

Purine analog

29

cytarabine (arabinofuranosyl cytidine)

pyrimidine analog

30

5-fluoruracil (5-FU)

pyrimidine analog; bioactivated

31

methotrexate

folic acid analog
DHFR inhibitor

32

bleomycin

antitumor - induces free radical formation --> DNA stran breaks

33

dactinomycin

antitumor
intercalates in DNA

34

doxorubicin

generates free radicals
Intercalate in DNA

35

daunorubicine

generates free radicals
Intercalate in DNA

36

busulfan

cross-links DNA

37

cyclophosphamide

cross links DNA at guanine

38

ifosfamide

cross-links DNA at guanine

39

carmustine

require bioactivation

40

lomustine

require bioactivation

41

semustine

require bioactivation

42

streptozocin

require bioactivation

43

paclitaxel

stabilizes polymerized microtubules in M phase

44

vincristine

vinca alkaloid binds B-tubulin
inhibits polymerization

45

vinblastine

vinca alkaloid binds B-tubulin
inhibits polymerization

46

Cisplatin

Cross-links DNA

47

carboplatin

Cross-links DNA

48

Etoposide

inhibits topoisomerase II

49

teniposide

inhibits topoisomerase II

50

irinotecan

inhibits topoisomerase I

51

topotecan

Inhibits topoisomerase I

52

hydroxyurea

inhibits ribonucleotide reductase -> inhibits DNA synthesis

53

prednisone

alters gene transcription

54

prednisolone

alters gene transcription

55

bevacizumab

monoclonal Ab vs VEGF

56

Erlotinib

EGFR TKR

57

Imatinib

TK inhibitor of BCR-ABL
philadelphia chromosome fusion gene in CML

58

rituximab

monoclonal Ab vs CD20

59

tamoxifen

selective estrogen receptor modulators

60

raloxifene

selective estrogen receptor modulators

61

trastuzumab

monoclonal Ab vs HER2

62

vemurafenib

small molecule inhibitor of BRAF oncogene