Hematology

Question 1

what is the first type of cell produced by the developing embryo

Answer 1

erythrocyte

Question 2

what percentage of tissue located in the bone marrow cavities of adults is fat

Answer 2

50%

Question 3

characteristics of pluripotent hematopoietic stem cells

Answer 3

possesses self-renewal ability, produces Pro generator cells committed to a single cell lineage, are morphologically unrecognizable

Question 4

in an adult, what are the two best areas for obtaining active bone marrow by aspiration

Answer 4

posterior iliac crest, sternum

Question 5

what is the normal ratio of myeloid to erythroid precursors in bone marrow M:E ratio

Answer 5

4:1

Question 6

what accurately describes hemopoietic growth factors

Answer 6

binds to Target cell receptors to express activity, May promote or suppress cell death, can stimulate or inhibit cell proliferation

Question 7

in the third month of gestation, what is the primary site of hematopoiesis

Answer 7

liver

Question 8

the mechanism that relays information about tissue oxygen levels to erythropoietin producing sites is located in the

Answer 8

kidney

Question 9

antigen independent lymphopoiesis occurs in primary lymphoid tissue located in the

Answer 9

thymus and bone marrow

Question 10

programmed cell death is called

Answer 10

apoptosis

Question 11

in what area of the bone marrow does hematopoiesis take place

Answer 11

cords

Question 12

bone marrow cellularity refers to the ratio of

Answer 12

hematopoietic tissue to adipose tissue

Question 13

interleukins and Colony stimulating factors are cytokines produced by

Answer 13

monocytes and T lymphocytes

Question 14

what is the approximate total blood volume in an adult

Answer 14

6 liters

Question 15

the myeloid progenitor cell can produce cells committed to

Answer 15

granulocytic, erythrocytic, monocytic, or Megakaryocytic lineages

Question 16

the largest hematopoietic cells in normal bone marrow are

Answer 16

megakaryocytes

Question 17

when evaluating a bone marrow aspirate smear, which finding is considered abnormal

Answer 17

the presence of 10% myeloblasts on the cell differential count

Question 18

as most blood cell lines mature, what is a good characteristic to look for

Answer 18

nucleus to cytoplasm ratio N:C ratio

Question 19

describe thrombopoietin (TPO)

Answer 19

hormone produced by the liver that stimulates megakaryopoeisis

Question 20

when the hepatic phase of fetal life is reactivated in an adult, hematopoiesis can be termed

Answer 20

myeloid metaplasia or extramedullary