Hematology

Question 1

ADAMTS13

Answer 1

It’s VWF cleaving enzyme and associated with TTP

Question 2

TTP Symptoms

Answer 2

Fever
AKI
Neuro ( seizure , Stroke , delirium )
Low platelets
Hemolytic anemia

Question 3

HUS

Answer 3

Fever ( diarrhea before due to E.coli )
AKI
Hemolytic anemia 
Low platelets 
NO NURO

Question 4

TTP Vs HUS

Answer 4

HUS : diarrhea , No Neuro , AKI with higher creatinine

TTP : ADAMTS13 , With neuro , less AKI

Question 5

Schistocytes seen in

Answer 5

DIC
TTP
HUS

Question 6

Waldenstrom Macroglobulinemia

Answer 6

Disorder of the B-cell ( IgM )

Question 7

Waldenstrom Macroglobulinemia presentation

Answer 7

Hyperviscosity ( High IgM )
Cryoglobulunemia ( Raynaud phenomenon )
Cold agglutinins disease

Question 8

Waldenstrom Macroglobulinemia Dx

Answer 8

Bone marrow biopsy

Dutcher bodies +IgM

Question 9

MUGS

Answer 9

Monoclonal gammopathy of undetermined significance
This is the precursor of two diseases
1. Multiple Myeloma ( IgG + IgA )
2. Walden storm macroglobulenemia

Question 10

Amyloidosis Major sites of clinically important dispositions

Answer 10

Kidney
Heart
Liver

Question 11

Amyloidosis DX

Answer 11

Tissue biopsy with Congo red staining.

Question 12

Esophageal cancer

Answer 12

Barret - Adenocarcinoma

Plummer Vinson - Sqamous cell carcinoma

Question 13

Prussian blue

Answer 13

It’s spider oblast is anemia

Question 14

Bite cells + Hence bodies

Answer 14

G6PD

Question 15

Coombs +

Answer 15

Autoimmune heamolysis

Question 16

Reedstenberg

Answer 16

Hodgkin disease

Question 17

High RDW

Answer 17

It’s only Iron deficiency Anemia

Question 18

Aur rods

Answer 18

AML

Question 19

Iron deficiency Anemia 2 only’s

Answer 19

• High RDW.

- Low ferritin. ( ferritin t store t )

Question 20

hypersegmented neutrophils

Answer 20

Folate + B12 deficiency

Question 21

Target Cell

Answer 21

Thalassemia

Question 22

All RBC production problems give you

Answer 22

Low retic count .. Either Folate + B12 or Thlasemia and iron def etc

No contents of the retic how we gonna make the retics

Question 23

The only Low MCV and High retic Count is

Answer 23

3 gene deletion

Question 24

Hypothyroidism Anemia is

Answer 24

Macrocytic Anemia
This Big MCV one
Also liver disease Macrocytic

Question 25

Very Well known medication that cause Folate deficiency

Answer 25

Phenytoin

Question 26

Reticulocytes

Answer 26

Larger Cells than RBs | They are retained placenta BIG ones

Question 27

Very low Hematocrit | Very low Hgb

Answer 27

25-30 | 8-10

Question 28

1 unit of Packed RBC

Answer 28

Raise the hematocrit (3 points) | Raise the Hgb ( 1 point )

Question 29

Warfarin Overdose reversed by

Answer 29

PCC Prothrombin complex concentrate 2 7 9 10 NOT FFP

Question 30

Tx. Hemophilia A&B VWD

Answer 30

Factor 8 or 9 / Desmopressin DDVAP | Factor 8 or / Desmopressin DDVAP

Question 31

NOAC Overdose

Answer 31

Idarusizumab

Question 32

FFP Replaces

Answer 32

Clotting Factors | It’s need blood type

Question 33

Hepcidin

Answer 33

Keep in the iron Trapped in the Store so you can’t use it

Question 34

Anisocytosis

Answer 34

Unequal RBC sizes

Question 35

HIT

Answer 35

IgG AB Against PF4 4-10 days after heparin More than 50% drop in platelets count TX is stop heparin + foundaparinux / argatroban / lipirudin Complications: Arterial and venous thrombosis

Question 36

Wells score

Answer 36

Risk assessment for DVT

Question 37

Thalassemia minor labs

Answer 37

RBC count normal Hgb normal RDW normal EXCEPT Low MCV

Question 38

Only thing change in the lab of thalassemia minors patient is

Answer 38

Low MCV .. It’s microcytic anemia

Question 39

Thalassemia Chromosomes A thalassemia B thalassemia

Answer 39

Chr.16 | Chr.11

Question 40

Most Accurate test for Thalasemia diagnosis

Answer 40

Genetic testing It’s autosomal recessive disease so A thalassemia Chr.16 B thalassemia Chr.11

Question 41

Normal Adult Hemoglobin component

Answer 41

A :97% A2 : 2 % F: 1%

Question 42

Disorder in the heme part of the Hgb is two

Answer 42

Heme - Iron def / Chronic disease | Protoporphyrin- Sideroblastic

Question 43

Tumor lysis syndrome

Answer 43

Associated with hematologic malignancies After initiation of cytotoxic Chemotherapy 1. High P ( phosphate and Potassium ) + Uric acid 2.Low Calcium ( the phosphate bind the calcium so more phosphate with bind more Ca making it low ) Manage with: Fluids Allopurinol + Rasburcase “ lowers uric acid “ Monitor the Arrhythmia’s ( because of Ca + K abnormality )