Hematology And Oncology Stuff

Question 1

Where does fetal erythropoiesis occur at different points in life

Answer 1

Yolk sac = 3-8 weeks

Liver = 6 weeks- birth

Spleen = 10-28 weeks Old

Bone marrow = 18 weeks -> rest of life

“Young Liver Synthesizes Blood”

Question 2

Blood components

Answer 2

1) Erythrocytes/ hematocrit
- usually 45%

2) Buffy coat: platelets and leukocytes
- 1% of total blood usually

3) plasma
- usually 55%
- contains no cells and is 90% water
- 10% is proteins with the majority being albumin (maintains oncotic pressure and is made in the liver)
- other proteins = globulins, transport proteins and fibrinogen

• plasma that has no proteins in it is called serum*

Question 3

What is the general lifespan for RBCs?

Answer 3

120 days

Question 4

What are the different types of globulins?

Answer 4

Alpha and beta = transport fats/metal ions/fat-soluble vitamins

Gamma = antibodies

Question 5

What are the dense granules that platelets have stored in them?

Answer 5

Calcium

ADP

Serotonin

Histamine

“CASH money”

Question 6

What are the alpha granules that platelets have sorted in them?

Answer 6

Von-willebrand factor

Fibrinogen

Fibronectin

Platelet factor 4

“alFa granules contain vWF, Fibrinogen, Fibronectin, platelet Factor Four”