Hematology (Coagulation Factors)

Question 1

what factors need vitamin K

Answer 1

9,10,7,2

Question 2

what factors are the actual clot

Answer 2

1-1a

Question 3

name for factor 1

Answer 3

fibrinogen

Question 4

name for factor 1a

Answer 4

fibrin

Question 5

factors are produced where

Answer 5

liver

Question 6

which factor is made by the endothelial cels of the blood vessels and not the liver

Answer 6

factor 8

Question 7

intrinsic pathway is under the control of what

Answer 7

heparin

Question 8

extrinsic pathway is under the control of what

Answer 8

warfarin

Question 9

what is the process that is used to activate vitamin k

Answer 9

gamma carboxylation

Question 10

what drug inhibits gamma carboxylation (activation of vitamin K)

Answer 10

warfarin

Question 11

what three drugs inhibit factor 10

Answer 11

heparin
riveroxaban
apixaban

Question 12

what are the 3 things made by the endothelial cells to help with keeping the blood vessel vasodialated so that platelets all stay in the middle

Answer 12

NO
PGI2
ADP-Dephosphatase

Question 13

role of heparin sulfate

Answer 13

attaches to antithrombin III and then cleaves factors 9,10 and 12

Question 14

where is antithrombin III made

Answer 14

liver

Question 15

what is lost in nephrotic syndrome and is responsible for the hypercoaguable state

Answer 15

antithrombin 3

Question 16

what inhibits antithrombin 3 causing the patient to be in a hypercoaguable state

Answer 16

oral contraception

Question 17

role of thrombomodulin

Answer 17

attaches to 2a and then attaches to protein c and then it cleaves 8a and 5a so that the rest of the coagulation pathway cannot occur and a clot won’t happen

Question 18

role of tPA

Answer 18

tPA takes plasminogen from the liver and turns it into plasmin and then it chops 1a (fibrin) into tiny pieces causing it to become a “Fibrin Split Product”

Question 19

4 Thrombolytic Drugs (tPA analogues)

Answer 19

Streptokinase
Urokinase
Alteplase
Retaplase

Question 20

risk factor for thrombolytic

Answer 20

excessive bleeding

Question 21

what do thrombolytics do

Answer 21

they induce the change of plasminogen to plasmin

Question 22

what is the drug that inhibits tPA

Answer 22

Aminocarpuic Acid

Question 23

first response to BV damage

Answer 23

neurogenic vasoconstriction

Question 24

2nd response to BV damage

Answer 24

endothelia release (vasoconstriction)

Question 25

3rd response to BV damage

Answer 25

vWF upregualtion

Question 26

GP1b binds to what

Answer 26

vWF

Question 27

what happens when Gp1b binds to vWF

Answer 27

Cox pathway is stimulated and TXA2 is produced

Question 28

what does thromboxane A2 do

Answer 28

causes the degranulation of the alpha and delta cells in the platelets so that ADP can be released

Question 29

what does ADP and ADP receptors on the platelet cells fo

Answer 29

causes the up regulation of GPIIb-IIIA

Question 30

what blocks the cox pathway

Answer 30

aspirin

Question 31

4 ADP Receptor (platelet) blocker drugs

Answer 31

Ticlopidine Clopidogrel Prasugrel Ticagrel

Question 32

3 GPIIb-IIIa receptor inhibitors

Answer 32

Abciximab Epitifibatide Tirofiban

Question 33

drugs for von wilder brand disease

Answer 33

desmopressin vasopressin *factor 8

Question 34

Gp1b deficiency is called

Answer 34

Bernard Solier

Question 35

GpIIIa deficiency is called

Answer 35

Glanzmen Disorder

Question 36

what factor activated factor 13

Answer 36

1A

Question 37

WHAT forms mesh work around clot

Answer 37

factor 13

Question 38

Drugs that inhibit Factor 10 (3)

Answer 38

Heparin Riveroxaban Apixaban

Question 39

Direct Thrombin inhibitors

Answer 39

Argatroban | Bivalrudin

Question 40

phosphodiesterase 3 inhibitor

Answer 40

Cilostazole