Hematology / Oncology

Question 1

4 causes of Microcytic Anemia

Answer 1

TICS

Thalassemia
Iron Deficiency
Anemia of Chronic Disease
Sideroblastic Anemia

Question 2

Elderly man with hypochromic, microcytic anemia is asymptomatic. Diagnostic Test?

Answer 2

Fecal Occult blood test and sigmoidoscopy

Suspect Colorectal cancer

Question 3

Precipitants of hemolytic crisis in pt with G6PD deficiency

Answer 3

Sulfonamides
Antimalarial drugs
Fava Beans

Question 4

Most common inherited cause of hypercoagulability

Answer 4

Factor V leiden Mutation

Question 5

Most common inherited bleeding disorder

Answer 5

Von Willebrand’s Disease

Question 6

Most common inherited hemolytic anemia

Answer 6

Hereditary Spherocytosis

Question 7

Pure RBC aplasia

Answer 7

Diamond-Blackfan Anemia

Question 8

Anemia associated with abscent radii and thumbs, diffuse hyperpigmentation, cafe au lait spots, microcephaly and pancytopenia

Answer 8

Fanconi’s Anemia

Question 9

Medications and Viruses that lead to aplastic anemia

Answer 9

Chloramphenicol
Sulfonamides
Radiation
HIV
Chemo Agents
Hepatitis
Parvovirus B19
EBV

Question 10

Distinguish Polycthemia Vera from 2 Plycythemia

Answer 10

Both have increase Hematocrit and RBC mass

Polycythemia Vera should have NORMAL 02 saturation and low erythropoietin levels

Question 11

Thrombotic Thrombocytopenic Purpura (TTP) pentad?

Answer 11

FAT RN

Fever
Anemia
Thrombocytopenia
Renal Dysfunction
Neurologic Abnormalities

Question 12

HUS Triad

Answer 12

Anemia
Thrombocytopenia
Acute renal failure

Question 13

Treatment for TTP?

Answer 13

Emergent Large Volume plasmapheresis
Corticosteroids
Anti-Platelet drugs

Question 14

Tx for Idiopathic Thrombocytopenic Purpura (ITP) in children

Answer 14

Usually resolves spontaneously

May require:
IVID and/or Steroids

Question 15

Which of the following are increased in DIC:

Fibrin Split products
D- Dimer
Fibrinogen
Platelets
Hematocrit

Answer 15

Fibrin split products increase
D-dimers increase

Platelets Decrease
Fibrinogen Decrease
Hematocrit Decrease

Question 16

8 y/o presents with hemarthrosis and increase PTT with normal PT and bleeding time. Diagnosis? Tx?

Answer 16

Hemophilia A or B; consider desmopression, or factor VIII or IX Supplements

Question 17

14 y/o girl presents with prolonged bleeding after dental surgery and with menses, normal PT, normal or increase PTT, and increase bleeding time. Diagnosis? Tx?

Answer 17

Von williebrand’s disease; treat with desmopressiin, FFP or Cryoprecipitate

Question 18

60 y/o AA man presents with bone pain. Workup for multiple myeloma might reveal?

Answer 18

Monoclonal gammopathy
Bence Jones proteinuria
Punched out lesions on Xray of skill and long bones

Question 19

Reed-Sternberg Cells

Answer 19

Hodgkin’s Lymphoma

Question 20

10 y/o boy presents with fever, weight loss, and night sweats. Exam shows anterior mediastinal mass. Suspected diagnosis?

Answer 20

Non-Hodgkin’s Lymphoma

Question 21

Microcytic Anemia with decrease serum iron, decrease total iron-binding capacity (TIBC) and normal or increase ferritin

Answer 21

Anemia of Chronic Disease

Question 22

Microcytic Anemia with decrease serum iron, decrease ferritin and increase TIBC

Answer 22

Iron Deficiency Anemia

Question 23

80 y/o man presents with fatigue, lymphadenopathy, splenomegaly, and isolated lymphocytosis. Suspected diagnosis

Answer 23

Chronic Lymphocytic Leukemia (CLL)

Question 24

The Lymphoma equivalent of CLL

Answer 24

Small Lymphocytic Lymphoma

Question 25

Late, Life-threatening complicatoin fo chronic myelogenous leukemia (CML)

Answer 25

Blast Crisis (Fever, Bone Pain, Splenomegaly, Pancytopenia)

Question 26

Auer rods on blood smear

Answer 26

Acute myelogenous leukemia (AML)

Question 27

AML Subtype associated with DIC

Answer 27

M3

Question 28

Electrolyte changes in Tumor lysis syndrome

Answer 28

Decrease - Ca Increase - K - Phosphate - Uric Acid

Question 29

Treatment for AML M3

Answer 29

Retinoic Acid

Question 30

50 year old man presents with early satiety, splenomegaly, and bleeding. Cytogenetics show t(9,22). Diagnosis?

Answer 30

CML

Question 31

Heinz Body

Answer 31

Intracellular inclusions seen in thalassemia G6PD Post-Splenectomy

Question 32

AR disorder with a defect in the GP IIB / IIIa platelet receptor and decrease platelet aggregation

Answer 32

Glanzmann's Thrombasthenia

Question 33

Virus associated with aplastic anemia in pt with sickle cell anemia

Answer 33

Parvovirus B19

Question 34

25 year old AA man with sickle cell anemia has sudden onset of bone pain. Pain management for crisis

Answer 34

02 Analgesia Hydration Transfusion NEED TO TO MORPHINE

Question 35

Significant cause of morbidity in thalassemia pt. Treatment?

Answer 35

Iron Overload use Deferoxamine