Hematology, TBP

Question 1

Most important RBC index

Answer 1

MCV

Question 2

Mechanism of anemia in an enlarged spleen

Answer 2

Increased sequestration

Question 3

Mechanism of anemia: Hereditary spherocytosis

Answer 3

Defect in cytoskeleton

Question 4

Mechanism of anemia: Paroxysmal nocturnal hemoglobinuria

Answer 4

Phosphatidylinositol glycan A (PIGA, needed for synthesis of glycosylphosphatidylinositol or GPI that anchors CD55 and CD59 that degrade complement) is lost, hence RBC is more prone to lysis by complement

Question 5

CD55 is aka

Answer 5

Decay accelerating factor (DAF)

Question 6

CD59 is aka

Answer 6

Membrane inhibitor of reactive lysis

Question 7

Complication of PNH

Answer 7

Venous thrombosis

Question 8

Organs most susceptible to venous thrombosis in PNH

Answer 8

1) Hepatic
2) Portal
3) Cerebral

Question 9

Organs involved in extravascular hemolysis

Answer 9

1) Spleen

2) Liver

Question 10

Complications of extravascular hemolysis

Answer 10

1) Hemosiderin deposition
2) Gallstones
3) Jaundice

Question 11

Jaundice and gallstones in extravascular hemolysis is due to

Answer 11

Elevated unconjugated bilirubin

Question 12

Complications of intravascular hemolysis

Answer 12

1) Unconjugated hyperbilirubinemia (jaundice and gallstones)
2) Hemoglobinemia
3) Hemoglobinuria
4) Hemosiderinuria

Question 13

Hemoglobinemia causes what renal disease

Answer 13

ATN

Question 14

Cell-associated condition: Spherocytes (2)

Answer 14

1) Hereditary spherocytosis

2) Immune hemolysis

Question 15

Cell-associated condition: Schistocytes (2)

Answer 15

1) Microangiopathic hemolytic anemia (TTP)

2) HUS

Question 16

Cell-associated condition: Target cells (2)

Answer 16

1) Hemoglobinopathies

2) Obstructive liver disease

Question 17

Cell-associated condition: Teardrop cells

Answer 17

Myelofibrosis

Question 18

Cell-associated condition: Rouleaux formation (2)

Answer 18

1) Increased glob ins (MM)

2) Decreased albumin

Question 19

Corrected reticulocyte count

Answer 19

Reticulocyte count x Hct / Normal Hct

Question 20

Decreased reticulocyte count is seen in

Answer 20

1) Primary bone marrow disorder
2) Iron deficiency
3) Vitamin B12 or folate deficiency

Question 21

Increased reticulocyte count is seen in

Answer 21

1) Hemolysis

2) Blood loss

Question 22

IDA: Ferritin

Answer 22

Decreased

Question 23

IDA: Serum iron

Answer 23

Decreased

Question 24

IDA: TIBC

Answer 24

Increased

Question 25

IDA: Transferrin saturation

Answer 25

Decreased

Question 26

Thalassemia: Ferritin

Answer 26

Normal

Question 27

Thalassemia: Serum iron

Answer 27

Normal

Question 28

Thalassemia: TIBC

Answer 28

Normal

Question 29

Thalassemia: Transferrin

Answer 29

Normal

Question 30

Anemia of chronic disease: Ferritin

Answer 30

Increased

Question 31

Anemia of chronic disease: Serum iron

Answer 31

Decreased

Question 32

Anemia of chronic disease: TIBC

Answer 32

Decreased

Question 33

Anemia of chronic disease: Transferrin saturation

Answer 33

Increased

Question 34

IDA: MCV

Answer 34

Microcytic

Question 35

Anemia of chronic disease: MCV

Answer 35

Microcytic

Question 36

Mechanism of IDA in pregnancy

Answer 36

Increased demands

Question 37

Ratio of serum iron to TIBC

Answer 37

Transferrin saturation

Question 38

Normal transferrin saturation

Answer 38

> 20%

Question 39

RBC morphology-associated anemia: Pencil cells

Answer 39

IDA

Question 40

Deficient production of Hgb due to mutation or complete loss of a glob in chain

Answer 40

Thalassemia

Question 41

Condition due to complete loss of one or more of the four copies of the α-globulin chain gene

Answer 41

α-Thalassemia