HEMATOPOIESIS

Question 1

Process of blood production (building up of blood components– RBC, WBC, and platelets)

Answer 1

Hematopoiesis

Question 2

INTRAUTERINE HEMATOPOIESIS PHASES (3)

Answer 2

Mesoblastic Phase
Hepatic Phase
Myeloid/ Medullary Phase

Question 3

YOLK SAC

Answer 3

Mesoblastic Phase

Question 4

LIVER

Answer 4

Hepatic Phase

Question 5

RED BM

Answer 5

Myeloid/ Medullary Phase

Question 6

Mesoblastic Phase Begins at

Answer 6

19th day of gestation

Question 7

Hepatic Phase Begins at

Answer 7

6 weeks of gestation

Question 8

Myeloid/ Medullary Phase Begins around

Answer 8

5th month of gestation

Question 9

first cell and doesn’t disappear even until adulthood

Answer 9

Primitive Nucleated Erythroblast

Question 10

Embryonic Hgb (3)

Answer 10

1. Gower I
2. Gower II
3. Portland

Question 11

Production of red blood cells, granulocytes, monocytes, and megakaryocytes

Answer 11

Hepatic Phase

Question 12

Alpha and gamma globin chain production (HbF)

Answer 12

Hepatic Phase

Question 13

Bone marrow producing mainly granulocytes

Answer 13

Myeloid/ Medullary Phase

Question 14

6th months of age gamma-beta globin chain switch

Answer 14

Myeloid/ Medullary Phase

Question 15

80-90% of bone marrow is ACTIVE BONE MARROW

Answer 15

Newborn

Question 16

60% of bone marrow is ACTIVE

Answer 16

Young Adult (Age 20)

Question 17

Older Adult: ___ bone marrow is ACTIVE AND ___ is FAT

Answer 17

40% ; 60%

Question 18

it is the ratio of marrow cells to fat (red marrow/yellow marrow)

Answer 18

CELLULARITY

Question 19

marrow has 30-70% hematopoietic cells

Answer 19

Normocellular

Question 20

marrow has >70% hematopoietic cells

Answer 20

Hypercellular/ Hyperplastic

Question 21

marrow has <30% hematopoietic cells

Answer 21

Hypocellular/ Hypoplastic

Question 22

marrow has few or no hematopoietic cells

Answer 22

Aplastic

Question 23

It is the ratio of granulocytes and their precursors to nucleated erythroid precursors

Answer 23

M:E (Myeloid: Erythroid) Ratio

Question 24

Normal M:E Ratio

Answer 24

3:1 or 4:1

Question 25

_____ and _____ are excluded from the M:E ratio

Answer 25

Lymphocytes and monocytes

Question 26

simply counting the # of types of WBC

Answer 26

Differential Count Smear

Question 27

special request to identify RBC morphology, especially blast cells

Answer 27

PBS

Question 27

Contains both alpha and beta polypeptide chain

Answer 27

globin

Question 28

semi-permeable so electrolytes can pass through

Answer 28

Cell membrane