Hematopoiesis 8/29

Question 1

What are the general functions of blood

Answer 1

• the media for transport in the body
• important in pH balance
• important in temperature control - bringing vasculature closer to the surface

Question 2

Blood is considered what type of tissue

Answer 2

connective tissue

Question 3

What does blood transport

Answer 3

nutrients, waste products (to go to liver/kidneys), signals (hormones, interleukins, cytokines, O2, CO2 etc.

Question 4

How do RBCs, Platelets, and WBCs interact with the blood

Answer 4

RBCs and platelets do their work in the blood stream

WBCs care carried to their site of action by the blood.

Question 5

What is the difference between plasma and serum?

Answer 5

Plasma- serum and clotting factors

Serum- clotting factors have been removed

Question 6

Are lab tests usually done on Plasma or serum?

Answer 6

serum

Question 7

When a patient is bleeding bc of lack of clotting factors a doctor can give them….

Answer 7

transfusion of fresh frozen plasma

Question 8

Where is the site of hematopoiesis during the mesoblastic phase? and how old is the patient?

Answer 8

2 weeks

in embryo very early on- in yolk sac

Question 9

Where is the site of hematopoiesis during the hepatic phase? and how old is the patient?

Answer 9

6 weeks

blood has started to develop in the liver of the fetus

Question 10

Where is the site of hematopoiesis during the Splenic phase? and how old is the patient?

Answer 10

2nd trimester

blood in liver and spleen

Question 11

Where is the site of hematopoiesis during the myeloid phase? and how old is the patient?

Answer 11

end of 2nd trimester

only have marrow producing blood in bones

Question 12

Where is the site of hematopoiesis after the age of 20?

Answer 12

major place of development is sternum and pelvis

fatty replacement in long bones

Question 13

What is sinusoidal circulation

Answer 13

branched blood vessels that come back together

Question 14

where do lymphocytes mature?

Answer 14

called immuno confident, released from bone marrow, and then fully matured out in lymphnodes or lymphoid part of gut

Question 15

Where do meyloid cells mature?

Answer 15

in bone marrow

Question 16

What is the structure of the bone marrow?

Answer 16

blood still made in the long bone
meyloid cells mature and then go into the blood
lymphocytes- called immuno confident and then fully matured in lymphnodes
sinusoidal circulation

Question 17

pluripotent

Answer 17

pluripotent hematopoetic stem cell (PHSC) can divide into another PHSC or other types of cells

Question 18

When does a cell become a progenitor cell?

Answer 18

when cells differentiate and become myeloid or lymphoid , it becomes unipotent

Question 19

Progenitor cell

Answer 19

means unipotent

can self propogate to a degree ( can reproduce sidway and down the chart)

Question 20

Precursor cells propogate…

Answer 20

down the chart

Question 21

Describe Red Blood Cells

Answer 21

• dont have a nucleus
• most numerous
• simple cells
• salmon pink in color
• about the size of the nucleus of the lymphocyte
• 90% full of hemaglobin
• has enzymes but no organelles

Question 22

Platelets

Answer 22

not a cell
from a megakaryocyte
no nucleus
lots of organelles and structure
looks like debris on slide

Question 23

WBCs have 2 groups of granulocytes which are

Answer 23

specific granulocytes and agranulocytes

also have azure granuals- pale blue and are actually lysosomes