HEME

Question 1

Treatment for Stage I-IIA NLPHL bulky or I-IIB

Answer 1

Rituximab chemo + ISRT 30-36 Gy

Question 2

B symptoms

Answer 2

Fever>100.4, night sweats, weight loss> 10% baseline in 6 months

Question 3

Who needs LP in lymphoma workpu

Answer 3

Primary cns, HIV-associated, primary testicular, bone marrow involvement, paranasal sinus primary, double-hit lymphoma

Question 4

Treatment of limited stage bulky DLBCL

Answer 4

RCHOP x6 + ISRT 30 Gy

Question 5

What is the NHL chemo regimen

Answer 5

R-CHOP, ritux, cyclopho, adria, vincrist, prednisolone

Question 6

Treatment of limited stage non-bulky DLBCL

Answer 6

RCHOP x3 –> PET CT D1-3: ISRT 30 Gy, D4-5: Rchop x 3 –> PET CT (D1-3: ESRT 30 Gy, D4-5: biopsy negative: ISRT, or just do RCHOP x4 if all disease resected on excisional biopsy.

Question 7

Ann arbor staging

Answer 7

Stage I: single lymphatic site or single extra lymphatic site, STAGE II, >=2 LN regions on the same side of diaphragm, Stage III, both sides of diaphragm, Stage IV diffuse disseminated involvement of 1 or more extranodal organs, B: b symptoms (HL only), E: extralymphatic tissue

Question 8

Treatment for Favorable Stage I-IIA HL

Answer 8

ABVDx2 –> PET CT D1-3: ISRT 20 Gy, D4: ABVD x 2 + ISRT 30 Gy, D5: biopsy (negative: ABVD x2 + ISRT 30 Gy positive: refractory pathway)

Question 9

What is the chemo regimen for HL

Answer 9

ABVD, adria, bleo, vincblastine, dacarb

Question 10

How to treat h. pylori positive translocation positive malt lymphoma

Answer 10

triple therapy and ISRT 24Gy/1.5Gy

Question 11

Hodgkin lymphoma type of cells

Answer 11

reedd sternberg

Question 12

IPI

Answer 12

Age>60, ECOG>1, Elevated LDH, >1 extranodal site, Stage III-IV

Question 13

Heart mean with lymphoma RT

Answer 13

<5 Gy (<15 Gy)

Question 14

Lab workup for suspected lymphom

Answer 14

CBC, CMP, LDH/ESR, HIV, Hepatitis panel, Beta 2,

Question 15

Submandibular gland mean

Answer 15

<11 Gy

Question 16

NLPHL markers

Answer 16

CD15-, CD30-, CD20+, CD45+

Question 17

Who needs BM biopsy in lymphoma workup

Answer 17

FL and DLBCL, HL only if unexplained cytopenias and negative PET CT

Question 18

Lung V5

Answer 18

<55%

Question 19

What markers are indicative of Hodgkin Lymphoma

Answer 19

CD15+, CD 30+, CD 20-ve

Question 20

Treatment for Unfavorable Stage I-IIA HL

Answer 20

ABVDx2 –> PET CT D1-3: ABVD x2 + ISRT 30 Gy, D4: eBEACOPP x 2 + ISRT 30 Gy), D5: biopsy (negative: ABVD x2 + ISRT 30 Gy positive: refractory pathway)

Question 21

Flipi-2

Answer 21

Age>60, Hgb<12 g/dl, LN>=6cm, elevated beta 2microglobulin, BM involvement

Question 22

How to treat h. pylori negative gastric malt

Answer 22

ISRT 24 Gy/2Gy, Rituximab

Question 23

What is the translocation that confers antibiotic resistance in gastric malt

Answer 23

t(11:18)

Question 24

How to treat Classical HL for pediatrics, Stage IA-IIA nonbulky

Answer 24

AV-PC x3, ISRT 21 Gy if partial response

Question 25

Treatment for Stage I-II follicular lymphoma

Answer 25

ISRT 24 Gy/2Gy

Question 26

Lung mean

Answer 26

<10 Gy

Question 27

Lung V20

Answer 27

<30%

Question 28

Treatment for PMBCL

Answer 28

daR-Epoch x 6 --> PET CT D1-3: NFT, D4-5: biopsy positive: ISRT 30 Gy + boost to residual disease 40-45 Gy

Question 29

What are HL unfavorable risk factors per GHSG

Answer 29

A: ESR>50, B: ESR>30, MMR>0.33, >2 nodal sites, any extranodal lesion

Question 30

How to treat Classical HL for pediatrics, Stage IB-IIB or bulky stage IIIA-IVA

Answer 30

ABVE-PC x 4, RER and CR observe, SER or PR: ISRT 21 Gy

Question 31

Clonality needed for multiple myeloma

Answer 31

bm clonal plasma cells>10% or plasmacytoma and one of CRAB-SLM

Question 32

What are the HL risk groups

Answer 32

Early stage (StageI and Stage II non-bulky) Advanced stage (Stage II bulky and Stage III-IV)

Question 33

How to treat solitary plasmacytoma

Answer 33

RT to 40-50 Gy

Question 34

How to treat h. pylori positive translocation negative malt lymphoma

Answer 34

triple abx, omeprazole, amox, clarith, repeat endoscopy, if positive, abx again, if negative, q3mo endoscopy until 18 mo then ISRT 24 in 12 if progressive or symptomatic

Question 35

Treatment for Stage I-IIA NLPHL (nonbulky

Answer 35

ISRT 30-36 Gy

Question 36

FLIPI-1

Answer 36

Age>60, Hgb<12g/dl, >=5 LN stations, Elevated LDH, Stage III-IV

Question 37

Thyroid Lymphoma RT constraint

Answer 37

V25<63.5%

Question 38

What is the RT dose for peds HL

Answer 38

21 Gy

Question 39

What defines bulky disease for Lymphoma

Answer 39

HL: 10 cm, DLBCL 6-10 cm, FL 7 cm

Question 40

Breast mean with lymphoma RT

Answer 40

<4 Gy (<15 Gy)

Question 41

What is the workup for Testicular Lymphoma?

Answer 41

AFP/b-HCG, Testicular US and exam, LP

Question 42

What is the management for primary testicular Lymphoma?

Answer 42

Radical inguinal orchiectomy then RCHOP x6 and IT methotrexate and contralateral testis RT to 30 Gy

Question 43

What is included in the primary CNS workup?

Answer 43

LP, slit lamp exam, testicular US and exam if older men

Question 44

What is the management for PCNSL?

Answer 44

R-MVP (ritux, methotrex, procarb, vincris) then consolidation Radiation

Question 45

What is the dose for consolidation RT for PCNSL?

Answer 45

CR: WBRT 23.4 Gy/1.8Gy, PR: WBRT 30.6Gy/1.8Gy + residual disease IMRT boost to 45 Gy/1.8Gy

Question 46

What is the anterior border of the WBRT field for PCNSL?

Answer 46

A posterior globe 5mm behind lens

Question 47

What is the inferior border of the WBRT field for PCNSL?

Answer 47

C2/C3

Question 48

Who should you avoid WBRT for PCNSL?

Answer 48

Age > 60

Question 49

What is the treatment for NKTCell lymphoma?

Answer 49

CCRT 50.4 Gy/1.8Gy + DeVIC (dex, etop, ifos, carbo)

Question 50

What are the standard treatment volumes for NKTCell Lymphoma?

Answer 50

Bilateral nasal cavity, bilateral anterior ethmoid sinus, bilateral hard palate, ipsi maxillary sinus

Question 51

two treatment options for mantle cell lymphoma

Answer 51

36 Gy alone or chemo then 24 for CR, 36 for PR

Question 52

chemo for stage I and II mantle cell lymphoma

Answer 52

Ritux + bendamustine + acalabrutinib

Question 53

BrECADD

Answer 53

Brentuximab vedotin, Etoposide, Cyclophosphamide, adriamycin, dacarbazine, dexamethasone