Heme 3 Flashcards by Mani Yavi

Q

what enzymes are inhibited by lead poisoning

A

ferrochelatase

ALA Hehydratase

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Q

antibiotic that:

inhibits peptidyltransferase

A

chloremphenical

streptogramin

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Q

antibiotic that:

blocks translocation

A

macrolides

linezolid

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Q

antibiotic that:

prevents attachment of tRNA

A

tetracyclines

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Q

antibiotic that:

inhibits RNA polymerase

A

rifampin

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Q

antibiotic that:

inhibits topoisomerase

A

fluoroquinilones

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Q

antibiotic that:

inhibits DHF reductase

A

TMP

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Q

test used to diagnose thalassemia

A

hemoglobin electrophoresis

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Q

microcytic anemia with difficulty swallowing and glossitis

A

plummer vincent

-iron def

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Q

microcytic anemia with greater than 3.5 HbA2

A

B minor

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Q

megaloblastic anemia not correctable with B12 or Folate

A

orotic aciduria

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Q

megaloblastic anemia with peripheral neuropathy

A

B12 def

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Q

microcytic anemia with basophilic stippling

A

lead poisoning

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Q

microcytic anemia thats reversible with B12

A

sideroblastic anemia

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Q

macrocytic anemia in HIV patient

A

zidovudine

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Q

normocytic anemia and red urine in the morning

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A

PNA

Q

normocytic anemia with elevated creatinine

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A

kidney failure

Q

what can cause aplastic anemia

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A

Virus

drugs

fanconis

Q

what is the defect in B thalassemia

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A

point mutation in splicing and promoter site

Q

what type of cells are seen in B thalassemia

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A

target

anistocytes

Q

what population is B thalassemia common

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A

mediterranean

Q

what population is a thalassemia common

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A

asian

african

Q

Hb seen in 4 deletion in a thalassemia

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A

Hb Barts (y4)

Q

Hb seen in 3 deletion in a thalassemia

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A

HbH (B4)

what causes basophilic stippling

inhibition of rRNA degradation

where are ringed sideroblasts found

BM

when would you see a crew cut appearance in X ray

B thalassemia Sickle cell

how can you differentiate B12 and folate def

B12 has neurological symptoms as well as increased methylmalonic acid

cells seen in lead poisoning

ringed sideroblasts basophilic stippling