Heme/Onc Pharm

Question 1

Heparin MOA

Answer 1

Cofactor in activation of antithrombin

Question 2

Heparin use

Answer 2

PE anticoagulation, MI, DVT

Follow PTT

Question 3

Heparin reversal

Answer 3

Protamine sulfate is + which binds - heparin

Question 4

LMWH compared to heparin

Answer 4

LMWH higher Xa action, longer t1/2; not reversible, no monitoring required

Question 5

HIT pathogenesis

Answer 5

IgG anti-heparin bound to PF4 causes thrombosis from immune complexes and also *thrombocytopenia (sounds like DIC!)

Question 6

Lepirudin and bivalirudin MOA

Answer 6

Hirudin derivatives used as alternative for heparin for anticoagulation for HIT

Question 7

Warfarin MOA

Answer 7

Interferes with vit-K dep. factors II, VII, IX, and X and proteins C & S

Question 8

Warfarin follow with

Answer 8

PT

Question 9

Heparin follow with

Answer 9

PTT

Question 10

Warfarin effects this part of pathway

Answer 10

The EX-PresidenT went to WARfarin (PT, extrinsic)

Question 11

Heparin and warfarin which can be used in pregnancy?

Answer 11

Heparin

Question 12

Warfarin use

Answer 12

CHRONIC anticoagulation post-STEMI or DVT prophylaxis

Question 13

Reversing warfarin?

Answer 13

give vitamin K and FFP

Question 14

Where does warfarin and heparin act in the body?

Answer 14

Liver - warfarin; heparin - blood

Question 15

Heparin vs. warfarin onset

Answer 15

Heparin - fast

Warfarin - slow

Question 16

Clot busting drugs have this ending

Answer 16

plase

Question 17

Thrombolytics MOA

Answer 17

Aid conversion of plasminogen to plasmin (aka, t-PA) resulting in thrombin and fibrin clot cleaving

Inc. PT and PTT but not platelet count

Question 18

Thrombolytic reversal

Answer 18

Aminocaproic acid

Question 19

How does ASA affect PT and PTT?

Answer 19

No effect

Question 20

ASA toxicities

Answer 20

Ulcers
Tinnitus (CN VIII)
ARF
TIN
GI bleeding
Reye's

Question 21

ADP receptor inhibitors?

Answer 21

Clopidogrel

Question 22

Clopidogrel MOA

Answer 22

Irreversible blockade of ADP receptor (GIIb/IIIa) so it can’t bind fibrinogen

Question 23

Abciximab MOA

Answer 23

GpIIb/III inhibitor mAb

Question 24

Etoposide is most active during which phases of the cell cycle?

Answer 24

DNA synthesis and G2

Question 25

Bleomycin is most active during which phases of the cell cycle?

Answer 25

MOA: free radical formation damages DNA

Question 26

Bleomycin toxicity

Answer 26

Pulmonary fibrosis